Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma.
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Summary
Most patients with mantle cell lymphoma and follicular lymphoma had epigenetic aberrations targeting the INK4/Rb pathway and the role of Rb methylation in disease or histologic transformation in follicle lymphoma warrants further study.
- Type
- article
- Published
- 2007-12-01
- Cited by
- 38
- References
- 30
- OpenAlex
- https://openalex.org/W2109553227
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40285072
Keywords
Mantle cell lymphoma, Follicular lymphoma, DNA methylation, Methylation, Cancer research
References
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- Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma
- Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [p16(INK4a), p15(INK4b), p14(ARF)] in mantle cell lymphoma
- Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.
- Mantle cell lymphoma in the Chinese: Clinicopathological features and treatment outcome
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- INK4d-Deficient Mice Are Fertile Despite Testicular Atrophy
Cited by
- Integrative oncogenomic analysis of microarray data in hematologic malignancies.
- DNA methylation in follicular lymphoma
- Nuclear remodeling as a mechanism for genomic instability in cancer.
- Genomische Aberrationen bei primären Lymphomen des Zentralnervensystems
- The incidence, natural history, biology, and treatment of transformed lymphomas.
- Effect of p16 on glucocorticoid response in a B-cell lymphoblast cell line
- Inactivation of the CDKN2A Tumor-Suppressor Gene by Deletion or Methylation Is Common at Diagnosis in Follicular Lymphoma and Associated with Poor Clinical Outcome
- Alterations of gene expression of RB pathway in Opisthorchis viverrini infection-induced cholangiocarcinoma
- Sustained proliferation in cancer: mechanisms and novel therapeutic targets
- Role of p16 in the pathogenesis of Langerhans cell histiocytosis
- DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family.
- Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma.
- Down-Regulated Expression of HSP70 in Correlation with Clinicopathology of Cholangiocarcinoma
- SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
- New Molecular Targets in Mantle Cell lymphoma
- Prognostic significance of epigenetic inactivation of p16, p15, MGMT and DAPK genes in follicular lymphoma
- Retinoblastoma as an Epigenetic Disease: A Proposal
- Rb family proteins in gastric cancer (review).
- Methylation of miR-155-3p in mantle cell lymphoma and other non-Hodgkin's lymphomas
- Epigenetic modulation in hematologic malignancies: challenges and progress.
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