The retinoblastoma tumour suppressor in development and cancer
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Summary
Since its discovery, the retinoblastoma tumour-suppressor protein has been a focal point of cancer research and accumulating evidence indicates a complex role for RB in cell proliferation, differentiation and survival.
- Type
- review
- Published
- 2002-12-01
- Cited by
- 794
- References
- 137
- OpenAlex
- https://openalex.org/W1998492363
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22937378
Keywords
Retinoblastoma, Suppressor, Context (archaeology), Cancer research, Retinoblastoma protein
References
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- Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7
- p107 is a suppressor of retinoblastoma development in pRb-deficient mice.
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- Toward an understanding of the functional complexity of the E2F and retinoblastoma families.
- Corepressors and retinoblastoma protein function.
- Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.
- Developmental rescue of an embryonic‐lethal mutation in the retinoblastoma gene in chimeric mice.
- Retinoblastoma protein partners.
- Apaf-1 is a transcriptional target for E2F and p53
- E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
- The pRB‐related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.
- Acetylation control of the retinoblastoma tumour-suppressor protein
- DNA replication control through interaction of E2F–RB and the origin recognition complex
- Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
- Extensive contribution of Rb‐deficient cells to adult chimeric mice with limited histopathological consequences.
- Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
- Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene.
- Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
- Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
Cited by
- Advances in Cancer Stem Cell Biology
- Coupling of caspase‐9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell‐type‐specific
- Effect of HIV-1 Vpr on Cell Cycle Regulators
- Cell-intrinsic requirement for pRb in erythropoiesis.
- Molecular biology of basal and squamous cell carcinomas.
- Transcriptional regulation of cellular senescence
- Dissecting the telomere-independent pathways underlying human cellular senescence
- Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1.
- FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy.
- Systematic Analysis of Residues in Conserved Region 3 of the Human Papillomavirus 16 E7 Oncoprotein
- Identification and functional characterisation of novel APC/C interacting proteins
- Role of multiple domains of T antigen in gene regulation and transformation
- Novel approaches for chemosensitization of breast cancer cells: the E1A story.
- In vivo studies of repressors of RNA polymerase III transcription
- Analyzing RB and E2F during the G1-S transition.
- Markers of cellular senescence.
- Oncogenic transformation and experimental models of human cancer.
- DNMT3b's Role in Hematopoietic Stem Cells
- G1 and S-phase checkpoints, chromosome instability, and cancer.
- Autophagy regulation in cancer development and therapy.
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