Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
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Summary
This review presents current knowledge on pathogen recognition through different families of PRRs and the increasingly complex signaling pathways responsible for activation of an inflammatory and antimicrobial response and medical implications are discussed.
- Type
- review
- Published
- 2009-04-01
- Cited by
- 2,959
- References
- 421
- Access
- Open access
- OpenAlex
- https://openalex.org/W2106248075
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21443977
Keywords
Pattern recognition receptor, Innate immune system, Biology, Immunology, Immune system
References
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- Toll-Like Receptor 4 Mediates Intracellular Signaling Without TNF-α Release in Response to Cryptococcus neoformans Polysaccharide Capsule1
- X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling
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- Potential requirement of a functional double-stranded RNA-dependent protein kinase (PKR) for the tumoricidal activation of macrophages by lipopolysaccharide or IFN-alpha beta, but not IFN-gamma.
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- Intraspecies Variation in the Emergence of Hyperinfectious Bacterial Strains in Nature
- Optimizing Dendritic Cell-Based Immunotherapy: Tackling the Complexity of Different Arms of the Immune System
- Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells.
- Association of Toll-Like Receptor 4 Polymorphisms with Diabetic Foot Ulcers and Application of Artificial Neural Network in DFU Risk Assessment in Type 2 Diabetes Patients
- Diminazene aceturate (Berenil) modulates LPS induced pro-inflammatory cytokine production by inhibiting phosphorylation of MAPKs and STAT proteins
- Exogenous Asymmetric Dimethylarginine (ADMA) in Pathogenesis of Ischemia-Reperfusion-Induced Gastric Lesions: Interaction with Protective Nitric Oxide (NO) and Calcitonin Gene-Related Peptide (CGRP)
- The Impact of Staphylococcus aureus-Associated Molecular Patterns on Staphylococcal Superantigen-Induced Toxic Shock Syndrome and Pneumonia
- Interesterified fat or palm oil as substitutes for partially hydrogenated fat during the perinatal period produces changes in the brain fatty acids profile and increases leukocyte-endothelial interactions in the cerebral microcirculation from the male offspring in adult life.
- Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media
- Differential antibacterial response of chicken granulosa cells to invasion by Salmonella serovars.
- Immunogenicity of a Glycoconjugate from Hydrazine‐Detoxified Lipopolysaccharide of Vibrio cholerae O139
- Comparative Analysis of Microbial Sensing Molecules in Mucosal Tissues with Aging
- Reduction of Marek's Disease Virus Infection by Toll-Like Receptor Ligands in Chicken Embryo Fibroblast Cells
- MiR-27-3p regulates TLR2/4-dependent mouse alveolar macrophage activation by targetting PPARγ.
- A guide to miRNAs in inflammation and innate immune responses
- Presentation matters: Impact of association of amphiphilic LPS with serum carrier proteins on innate immune signaling
- 25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection
- The medicinal uses, toxicities and anti-inflammatory activity of Polyalthia species (Annonaceae).
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