Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
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Summary
In claudin-5–deficient mice, the size-selective loosening of the blood-brain barrier was selectively affected, which provides new insight into the basic molecular physiology of BBB and opens a new way to deliver potential drugs across the BBB into the central nervous system.
- Type
- article
- Published
- 2003-05-12
- Cited by
- 1,868
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2104567497
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14085307
Keywords
Claudin, Blood–brain barrier, Tight junction, Biology, Central nervous system
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- Blood-brain barrier genomics, proteomics, and new transporter discovery
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- The complexus adhaerens of mammalian lymphatic endothelia revisited: a junction even more complex than hitherto thought
- Critical Role of Tight Junctions in Drug Delivery across Epithelial and Endothelial Cell Layers
- Blood–CSF barrier function in the rat embryo
- RNAi‐mediated reversible opening of the blood‐brain barrier
- In vitro models of the blood-brain barrier.
- Hepatitis C Virus entry: the early steps in the viral replication cycle
- Role of claudin species–specific dynamics in reconstitution and remodeling of the zonula occludens
- Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability.
- Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain.
- Unique Cell Type-Specific Junctional Complexes in Vascular Endothelium of Human and Rat Liver Sinusoids
- Alteration in P‐glycoprotein at the blood–brain barrier in the early period of MCAO in rats
- Age-related changes in brain support cells: Implications for stroke severity
- The blood-brain barrier-gatekeeper to neuronal homeostasis: clinical implications in the setting of stroke.
- Cerebrovascular and blood–brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology
- Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors
- MMP-Mediated Disruption of Claudin-5 in the Blood–Brain Barrier of Rat Brain After Cerebral Ischemia
- Central regulation of Blood Brain Barrier integrity during hyperalgesia
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