Alteration in P‐glycoprotein at the blood–brain barrier in the early period of MCAO in rats
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Summary
The aim of this work was to investigate the alteration in P‐glycoprotein at the blood–brain barrier (BBB) after middle cerebral artery occlusion (MCAO) in rats.
- Type
- article
- Published
- 2013-05-01
- Cited by
- 53
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W1598271522
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6003467
Keywords
Blood–brain barrier, Medicine, Staining, Nitric oxide synthase, Western blot
References
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- Role of drug efflux carriers in the healthy and diseased brain
- Valproic Acid Attenuates Blood–Brain Barrier Disruption in a Rat Model of Transient Focal Cerebral Ischemia: The Roles of HDAC and MMP-9 Inhibition
- Differential regulation of transport proteins in the periinfarct region following reversible middle cerebral artery occlusion in rats
- HZ08, a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ADM.
- Pregnane X receptor (PXR) activation: A mechanism for neuroprotection in a mouse model of Niemann–Pick C disease
- Matrix Metalloproteinase-Mediated Disruption of Tight Junction Proteins in Cerebral Vessels is Reversed by Synthetic Matrix Metalloproteinase Inhibitor in Focal Ischemia in Rat
- A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs.
- Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult
- In Vitro and In Vivo Study of CJY, an Isoflavone, on P-Glycoprotein Function in Rats
- Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion.
- Drug resistance in brain diseases and the role of drug efflux transporters
- COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats.
- Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia
- Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.
- Pericyte-derived Glial Cell Line-derived Neurotrophic Factor Increase the Expression of Claudin-5 in the Blood–brain Barrier and the Blood-nerve Barrier
- Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.
- Functional Expression and Localization of P-glycoprotein in the Central Nervous System: Relevance to the Pathogenesis and Treatment of Neurological Disorders
- Mitochondria, oxidative metabolism and cell death in stroke.
- The development of stroke therapeutics: promising mechanisms and translational challenges.
Cited by
- Regulation of ABC Efflux Transporters at Blood-Brain Barrier in Health and Neurological Disorders
- In vitro and in vivo study of dolichyl phosphate on the efflux activity of P‐glycoprotein at the blood–brain barrier
- Modulation of P‐glycoprotein in rat brain microvessel endothelial cells under oxygen glucose deprivation
- YiQiFuMai powder injection ameliorates blood–brain barrier dysfunction and brain edema after focal cerebral ischemia–reperfusion injury in mice
- Regulation of P-glycoprotein efflux activity by Z-guggulsterone of Commiphora mukul at the blood-brain barrier.
- Influence of different hypoxia types on p-glycoprotein functional activity and expression
- Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies.
- GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway.
- Transporters as Drug Targets in Neurological Diseases
- Long-Term Alteration of Reactive Oxygen Species Led to Multidrug Resistance in MCF-7 Cells
- Time-course investigation of blood–brain barrier permeability and tight junction protein changes in a rat model of permanent focal ischemia
- Exenatide improves liver mitochondrial dysfunction and insulin resistance by reducing oxidative stress in high fat diet-induced obese mice.
- Spatiotemporal Changes in P-glycoprotein Levels in Brain and Peripheral Tissues Following Ischemic Stroke in Rats
- Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?
- Expression of P-Glycoprotein in the Blood-Brain Barrier and Its Interaction with Redox State in Cerebral Ischemia and Ischemia-Reperfusion
- SLC and ABC Transporters: Expression, Localization, and Species Differences at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers
- Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies
- Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease.
- Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions
- Neurovascular unit transport responses to ischemia and common coexisting conditions: smoking and diabetes.
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