Drug and gene targeting to the brain with molecular trojan horses
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Summary
Molecular Trojan Horses, such as endogenous peptides, modified proteins or peptidomimetic monoclonal antibodies, are one way of tricking the brain into allowing these molecules to pass.
- Type
- review
- Published
- 2002-02-01
- Cited by
- 462
- References
- 65
- OpenAlex
- https://openalex.org/W1981956388
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28592756
Keywords
Monoclonal antibody, Peptidomimetic, Trojan, Drug, Blood–brain barrier
References
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- In Vivo Gene Transfer by Intravenous Administration of Stable Cationic Lipid/DNA Complex
- Transport Across the Primate Blood-Brain Barrier of a Genetically Engineered Chimeric Monoclonal Antibody to the Human Insulin Receptor
- Pharmacokinetics and blood-brain barrier transport of [3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system.
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- Neuroprotection in Transient Focal Brain Ischemia After Delayed Intravenous Administration of Brain-Derived Neurotrophic Factor Conjugated to a Blood-Brain Barrier Drug Targeting System
- Retention of biologic activity of human epidermal growth factor following conjugation to a blood-brain barrier drug delivery vector via an extended poly(ethylene glycol) linker.
- Carrier-mediated or specialized transport of drugs across the blood-brain barrier.
- Peptidases, Peptides, and the Mammalian Blood–Brain Barrier
- Human brain microvascular DR‐antigen
- Herpes Vector-Mediated Delivery of Marker Genes to Disseminated Central Nervous System Tumors
Cited by
- Brain-Targeted Drug Delivery
- Magnetic Resonance Guided Focused Ultrasound: A New Technology for Clinical Neurosciences
- Systemic gene delivery to the central nervous system using Adeno-associated virus
- A multifunctional polymeric nanotheranostic system delivers doxorubicin and imaging agents across the blood-brain barrier targeting brain metastases of breast cancer.
- Drug transport into the central nervous system: using newer findings about the blood–brain barriers
- Surface modification of PGP for a neutrophil–nanoparticle co-vehicle to enhance the anti-depressant effect of baicalein
- Current in vitro and in silico models of blood-brain barrier penetration: a practical view.
- 6 A Practical Approach to Computational Models of the Blood-Brain Barrier
- Développement de vecteurs lentiviraux régulables pour le transfert de gène dans le système nerveux central
- Engineering Biomaterials for Regenerative Medicine: Novel Technologies for Clinical Applications
- Prediction of brain target site concentrations on the basis of CSF PK: Impact of mechanisms of blood-to-brain transport and within brain distribution
- Brain Delivery of Chemotherapeutics in Brain Cancer.
- Interactions of endogenous and exogenous molecules with the human blood-brain barrier
- The “fate” of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood–brain barrier crossing and trafficking into the central nervous system
- rAAV-Mediated Gene Transfer For Study of Pathological Mechanisms and Therapeutic Intervention in Canavan's Disease: A Dissertation
- Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas
- Tissue Non-specific Alkaline Phosphatase (TNAP) in Vessels of the Brain.
- Acute effects of short‐chain alkylglycerols on blood‐brain barrier properties of cultured brain endothelial cells
- Toxins and derivatives in molecular pharmaceutics: Drug delivery and targeted therapy.
- Ultrasound-induced blood-brain barrier opening for drug delivery.
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