Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation
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Summary
The results show that dietary methyl supplementation of a/a dams with extra folic acid, vitamin B12, choline, and betaine alter the phenotype of their Avy/a offspring via increased CpG methylation at the AvY locus and that the epigenetic metastability which confers this lability is due to the Avy transposable element.
- Type
- article
- Published
- 2003-08-01
- Cited by
- 2,004
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2100489386
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10707071
Keywords
Transposable element, Biology, Epigenetics, DNA methylation, Genetics
References
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Cited by
- Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice.
- Reduced Representation Bisulfite Sequencing of Human Neutrophils Reveals Widespread Inter-Individual Epigenetic Variation
- Perturbation of epigenetic status by toxicants.
- Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead.
- CpG island methylator phenotype in cancer
- Folate and its preventive potential in colorectal carcinogenesis. How strong is the biological and epidemiological evidence?
- Influence of human genetic variation on nutritional requirements.
- Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics.
- Folate: a magic bullet or a double edged sword for colorectal cancer prevention?
- Epigenetic integration of environmental and genomic signals in honey bees: the critical interplay of nutritional, brain and reproductive networks
- Is Epigenetics an Important Link between Early Life Events and Adult Disease?
- Superoxide dismutase 1 knockdown induces oxidative stress and DNA methylation loss in the prostate
- Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring.
- A genomic point-of-view on environmental factors influencing the human brain methylome
- Developmental origins of health and disease: experimental and human evidence of fetal programming for metabolic syndrome
- Distribution of a marker of germline methylation differs between major families of transposon-derived repeats in the human genome
- Epigenetic programming by maternal nutrition: shaping future generations.
- Environmental regulation of the neural epigenome.
- Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
- Epigenetics in Sports
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