Effect of phorbol ester treatment on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.
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Summary
Interestingly, PMA reduced cleavage induced by the topoisomerase II-reactive DNA intercalator 4'-(9-acridinylamino)methanesulfon-m-anisidide by 2-fold, suggesting that specific drug-DNA interactions could partially overcome the PMA-induced effect that resulted in decreased etoposide-induced, topoisomers enzyme II-mediated DNA cleavage.
- Type
- article
- Published
- 1988-12-01
- Cited by
- 39
- References
- 84
- OpenAlex
- https://openalex.org/W2098188843
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24406846
Keywords
Topoisomerase, Etoposide, Protein kinase C, Cellular differentiation, Molecular biology
References
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- Expression of transfected DNA depends on DNA topology.
Cited by
- Clinical implications of multidrug resistance to chemotherapy.
- Exploring the Role of Topoisomerase II Beta in Macrophage Maturation and Pro-inflammatory Cytokine Production
- Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors.
- Phorbol regulation of topoisomerases I and II in human leukemia cells. Studies in an additional cell pair sensitive or resistant to phorbol-induced differentiation.
- Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.
- Translocation and activation of protein kinase C by the plasma cell tumor-promoting alkane pristane.
- Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein.
- Role of calcium in toxic and programmed cell death.
- Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells.
- L-Glutamic Acid Modulates the Cytotoxic Effect of Tumor Necrosis Factor on the HL-60 Cell Line
- Topoisomerases, New Targets in Cancer Chemotherapy
- Effect of bryostatin 1 on drug-induced, topoisomerase II-mediated DNA cleavage and topoisomerase II gene expression in human leukemia cells.
- Time course of phorbol-12-myristate-13-acetate (PMA)-induced down-regulation of topoisomerase II in human leukemia cells.
- Curcumin abolishes apoptosis resistance of calcitriol‐differentiated HL‐60 cells
- Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs.
- Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy‐related monocytic leukemia with a 9;11 translocation
- Etoposide sensitivity and topoisomerase II activity in Chinese hamster V79 monolayers and small spheroids.
- Establishment of a human leukemia subline resistant to the growth‐inhibitory effect of 12‐o‐tetradecanoylphorbol 13‐acetate (TPA) and showing non‐P‐glycoprotein‐mediated multi‐drug resistance
- The effect of staurosporine on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells
- Side-chain-modified analogs of calcitriol cause resistance of human HL-60 promyelocytic leukemia cells to drug-induced apoptosis.
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