Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.
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Summary
Results strongly suggest that AP-1 is at the receiving end of a complex pathway responsible for transmitting the effects of phorbol ester tumor promoters from the plasma membrane to the transcriptional machinery.
- Type
- article
- Published
- 1987-06-19
- Cited by
- 2,597
- References
- 48
- OpenAlex
- https://openalex.org/W1967004332
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23154076
Keywords
Biology, Promoter, Heterologous, Molecular biology, Transcription factor
References
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- In vitro transcription: whole-cell extract.
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- Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts
- Tumor promoter 12-O-tetradecanoylphorbol 13-acetate stimulates simian virus 40 induction by DNA-damaging agents and tumor initiators
- Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts
- 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region
- Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer
- Tumor-promoting phorbol esters induce angiogenesis in vitro.
- Affinity purification of sequence-specific DNA binding proteins.
- Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
- Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene
- Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene.
- Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element.
Cited by
- The effects of cell adhesion on the growth and protein productivity of animal cells
- Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation
- Risk factors inducing the persistence of high‐risk genital papillomaviruses in the normal cervix
- Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity.
- Two cytotoxic cell proteinase genes are differentially sensitive to sodium butyrate.
- Occupancy of upstream regulatory sites in vivo coincides with major histocompatibility complex class I gene expression in mouse tissues
- Retinoic acid-induced down-regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif
- Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism.
- The intragenic enhancer of human immunodeficiency virus type 1 contains functional AP-1 binding sites
- A highly conserved intronic sequence is involved in transcriptional regulation of the alpha 1(I) collagen gene.
- Molecular oncogenetics of metastasis.
- A member of the activator protein 1 family found in keratinocytes but not in fibroblasts required for transcription from a human papillomavirus type 18 promoter
- Positive and negative transcriptional elements of the human type IV collagenase gene
- A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle.
- Hepadnavirus enhancer and its binding proteins
- Tissue-specific expression from a compound TATA-dependent and TATA-independent promoter
- Molecular signals in B cell activation. I. Differential refractory effects of incomplete signaling by ionomycin or PMA relate to autocrine IL-2 production and IL-2R expression.
- Cell-type-specific early response gene expression during plasmacytoid differentiation of human B lymphocytic leukemia cells.
- A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrade the connective tissue matrix.
- c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.
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