Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein.
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Summary
Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinases, suppressed growth and induced differentiation in HL-205 cells, a clonal population of the human promyelocytic HL-60 leukemia cells, and in K-562-J cells, an erythroid maturation marker.
- Type
- article
- Published
- 1990-05-01
- Cited by
- 241
- References
- 33
- OpenAlex
- https://openalex.org/W1789961596
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8501023
Keywords
Genistein, Molecular biology, Population, Monoclonal antibody, Biology
References
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- Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.
- Surface markers on leukemia and lymphoma cells: recent advances.
- Cancer as a disease of DNA organization and dynamic cell structure.
- Reduced formation of protein-associated DNA strand breaks in Chinese hamster cells resistant to topoisomerase II inhibitors.
- Breakage of DNA and alterations in folded genomes by inducers of differentiation in Friend erythroleukemic cells.
- Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.
- Protein that induces cell differentiation causes nicks in double‐stranded DNA
- Translocation of protein kinase C in human leukemia cells susceptible or resistant to differentiation induced by phorbol 12-myristate 13-acetate.
- Regulation of biosynthesis and phosphorylation of P210bcr/abl protein during differentiation induction of K 562 cells.
- Cannabinoids induce incomplete maturation of cultured human leukemia cells.
- Appearance of strand breaks in the nuclear DNA of terminally differentiating vaginal epithelium.
- DNA topoisomerases as targets for cancer therapy.
- DNA strand breaks and ADP-ribosyl transferase activation during cell differentiation
- Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells.
- X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution.
- Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases.
- Effect of phorbol ester treatment on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.
- DNA degradation in terminally differentiating lens fiber cells from chick embryos.
Cited by
- Effects of Genistein Isoflavone (4′,5′,7-Trihydroxyisoflavone) and Dexamethasone on Functional Characteristics of Spermatozoa
- Genistein Induces Apoptosis in T Lymphoma Cells via Mitochondrial Damage
- Kinase Inhibitors in Cancer Therapy
- Inhibition of choriocapillaris regeneration with genistein.
- Phytoestrogene, Phytogestagene und Phytoandrogene
- Anticancer therapeutic potential of soy isoflavone, genistein.
- Determining the intracellular concentrations of flavonoids in MDA-MB-231 cells using HPLC-coupled mass spectrometry
- Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents
- Antitumor Activities of 2-Methoxyestradiol on Cervical and Endometrial Cancers In Vitro and In Vivo
- Isoflavone effects on insulin like growth factors and breast cancer.
- Protein kinase inhibitors: probes for the functions of protein phosphorylation.
- Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors.
- Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation.
- Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis.
- Role of Bcr-Abl kinase in resistance to apoptosis.
- Mechanisms of Cancer Chemoprevention by Soy Isoflavone Genistein
- Effect of endocrine disruptors on the male mouse reproductive system
- Enhancement of experimental colon cancer by genistein.
- Transforming Growth Factor-β1 Induction of Novel Extracellular Matrix Proteins That Trigger Resistance to Tumor Necrosis Factor Cytotoxicity in Murine L929 Fibroblasts (*)
- bcr/abl expression in 32D cl3(G) cells inhibits apoptosis induced by protein tyrosine kinase inhibitors.
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