Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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Summary
It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
- Type
- review
- Published
- 2009-05-22
- Cited by
- 15,524
- References
- 67
- Access
- Open access
- OpenAlex
- https://openalex.org/W2097259163
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4598043
Keywords
Warburg effect, Anaerobic glycolysis, Cancer cell, Oxidative phosphorylation, Glycolysis
References
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- Glucose utilization in vivo by human pulmonary neoplasms
- Pyruvate kinase M2 is a phosphotyrosine-binding protein
- Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
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- SEPP1 and FoxM1 regulate oxidative stress-mediated radiation response
- Activation of fibroblasts in cancer stroma.
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- Adding a combination of hydroxycitrate and lipoic acid (METABLOC™) to chemotherapy improves effectiveness against tumor development: experimental results and case report
- Merging transcriptomics and metabolomics - advances in breast cancer profiling
- Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors.
- Leukemia Inhibitory Factor (LIF)-dependent, Pluripotent Stem Cells Established from Inner Cell Mass of Porcine Embryos
- On acetyl-CoA as a gauge of cellular metabolic state.
- Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors
- Targeting tumor hypoxia in nasopharyngeal carcinoma
- p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.
- Warburg Effect and Redox Balance
- PPARγ contributes to PKM2 and HK2 expression in fatty liver
- Taurine: Energy drink for T cells
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