Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways.
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Summary
It is shown that 98% ofInv(3)/t(3;3) myeloid malignancies harbor mutations in genes activating RAS/receptor tyrosine kinase (RTK) signaling pathways, suggesting recognition of inv(3/t( 3;3);3)Myeloidmalignancies as a single disease entity irrespective of blast count.
- Type
- article
- Published
- 2015-01-01
- Cited by
- 94
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2095429270
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206932526
Keywords
Myeloid leukemia, Myeloid, Cancer research, Biology, Mutation
References
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Cited by
- Clinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors.
- 3q26/EVI1 rearrangements in myeloid hemopathies: a cytogenetic review.
- ACUTE LEUKEMIAS XV
- Genes break barrier between MDS and AML.
- ST2: the biomarker at the heart of GVHD severity.
- Toward Individualized Therapy in Acute Myeloid Leukemia: A Contemporary Review.
- Acute myeloid leukaemia and myelodysplastic syndromes with 50% or greater erythroblasts: a diagnostic conundrum
- T-replete haploidentical allogeneic transplantation using post-transplantation cyclophosphamide in advanced AML and myelodysplastic syndromes
- Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance.
- Review: Aberrant EVI1 expression in acute myeloid leukaemia
- Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
- Predictive value of high EVI1 expression in AML patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation in first CR
- Genomic Classification and Prognosis in Acute Myeloid Leukemia
- Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia
- Rigosertib in myelodysplastic syndromes (MDS)
- The New Clinicopathologic and Molecular Findings in Myeloid Neoplasms With inv(3)(q21q26)/t(3;3)(q21;q26.2).
- Buparlisib, a PI3K inhibitor, demonstrates acceptable tolerability and preliminary activity in a phase I trial of patients with advanced leukemias
- Mutational landscape and gene-expression patterns in adult acute myeloid leukemias with monosomy 7 as a sole abnormality
- Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.
- Quality Assurance Guided FISH-Analysis for Optimal Detection of AMLAssociated Chromosomal Aberrations
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