Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways.

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Summary

It is shown that 98% ofInv(3)/t(3;3) myeloid malignancies harbor mutations in genes activating RAS/receptor tyrosine kinase (RTK) signaling pathways, suggesting recognition of inv(3/t( 3;3);3)Myeloidmalignancies as a single disease entity irrespective of blast count.

Type
article
Published
2015-01-01
Cited by
94
References
61
Access
Open access

Keywords

Myeloid leukemia, Myeloid, Cancer research, Biology, Mutation

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