Gata2 is required for HSC generation and survival
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Summary
GATA2 function is essential for the generation of HSCs during the stage of endothelial-to-hematopoietic cell transition and thereafter for HSC survival.
- Type
- article
- Published
- 2013-08-01
- Cited by
- 246
- References
- 36
- OpenAlex
- https://openalex.org/W2047997305
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6488418
Keywords
GATA2, Haematopoiesis, Biology, Embryonic stem cell, Cell biology
References
- The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region.
- Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment.
- Characterization of the first definitive hematopoietic stem cells in the AGM and liver of the mouse embryo.
- Fate tracing reveals the endothelial origin of hematopoietic stem cells
- Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system.
- In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
- An early haematopoietic defect in mice lacking the transcription factor GATA-2
- Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors.
- Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta.
- Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo.
- Genetic framework for GATA factor function in vascular biology
- Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning.
- Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7.
- Whole-mount three-dimensional imaging of internally localized immunostained cells within mouse embryos
- Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function.
- A Novel Complex, RUNX1-MYEF2, Represses Hematopoietic Genes in Erythroid Cells
- Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.
- Runx1 is required for the endothelial to hematopoietic cell transition but not thereafter
- RBPjκ-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells
- Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo
Cited by
- Endothelial‐to‐hematopoietic transition: Notch‐ing vessels into blood
- Myelodysplastic syndromes and acute leukemia with genetic predispositions: a new challenge for hematologists
- Myeloid malignancies with somatic GATA2 mutations can be associated with an immunodeficiency phenotype
- Role of the Notch1 TAD in embryonic development and hematopoiesis
- Missing Cells: Pathophysiology, Diagnosis, and Management of (Pan)Cytopenia in Childhood
- Contribution of the GATA2 transcription factor to the development and progression of myeloid disorders
- Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature
- Hematopoietic Signaling Mechanism Revealed From a Stem/Progenitor Cell Cistrome
- Human Cytomegalovirus Latency: Targeting Differences in the Latently Infected Cell with a View to Clearing Latent Infection
- Human cytomegalovirus latency and reactivation in and beyond the myeloid lineage
- Developmental hematopoiesis: ontogeny, genetic programming and conservation.
- Hematopoietic Transcriptional Mechanisms: From Locus-Specific to Genome-Wide Vantage Points
- A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia.
- Haematopoietic and immune defects associated with GATA2 mutation
- From transplantation to transgenics: mouse models of developmental hematopoiesis.
- Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
- Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo
- Cbfb deficiency results in differentiation blocks and stem/progenitor cell expansion in hematopoiesis
- Mechanism governing a stem cell-generating cis-regulatory element
- Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence
Related papers
- Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development
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- Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis
- Runx1 is involved in primitive erythropoiesis in the mouse.
- Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo
- RUNX1 and the endothelial origin of blood.