Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.
Explore this paper's citation graph
Summary
An international panel to provide updated evidence- and expert opinion-based recommendations for diagnosis and management of acute myeloid leukemia in adults includes a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.
- Type
- review
- Published
- 2017-01-26
- Cited by
- 5,223
- References
- 312
- Access
- Open access
- OpenAlex
- https://openalex.org/W2559537906
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7366076
Keywords
Medicine, Expert opinion, Minimal residual disease, Genetic testing, Disease
References
- New designs for phase 2 clinical trials.
- Interleukin-4 Stimulates Proliferation and Growth of T-Cell Acute Lymphoblastic Leukemia Cells by Activating mTOR Signaling
- Anthracycline dose intensification in acute myeloid leukemia.
- Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure.
- Prognosis and Therapy When Acute Promyelocytic Leukemia and Other “Good Risk” Acute Myeloid Leukemias Occur as a Therapy-Related Myeloid Neoplasm
- Comparative outcomes of donor graft CD34+ selection and immune suppressive therapy as graft-versus-host disease prophylaxis for patients with acute myeloid leukemia in complete remission undergoing HLA-matched sibling allogeneic hematopoietic cell transplantation.
- Chemotherapy followed by modified donor lymphocyte infusion as a treatment for relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation without in vitro T‐cell depletion: superior outcomes compared with chemotherapy alone and an analysis of prognostic factors
- Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
- MRD in AML: it is time to change the definition of remission.
- A New Statistical Method for Dose-Finding Based on Efficacy and Toxicity in Early Phase Clinical Trials
- Overall Survival in Older Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) with >30% Bone Marrow Blasts Treated with Azacitidine By Cytogenetic Risk Status: Results of the AZA-AML-001 Study
- Autologous stem cell transplantation for adult acute leukemia in 2015: time to rethink? Present status and future prospects
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
- Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies
- Tolerability and Clinical Activity of Post-Transplantation Azacitidine in Patients Allografted for Acute Myeloid Leukemia Treated on the RICAZA Trial
- A comparison of Daunorubicin/Ara-C (DA) versus Daunorubicin/Clofarabine (DClo) and two versus three courses of total treatment for older patients with AML and high risk MDS: results of the UK NCRI AML16 Trial [Abstract]
- Conditioning intensity in middle-aged patients with AML in first CR: no advantage for myeloablative regimens irrespective of the risk group–an observational analysis by the Acute Leukemia Working Party of the EBMT
- Immunotherapy in acute myeloid leukemia
- FLT3 Tyrosine Kinase Inhibition as a Paradigm for Targeted Drug Development in Acute Myeloid Leukemia.
- Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high‐risk myelodysplastic syndrome:
Cited by
- Outcomes of patients diagnosed with acute myeloid leukemia after solid organ transplantation
- Treatment of acute myeloid leukemia in the next decade - Towards real-time functional testing and personalized medicine.
- Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia
- Can we forecast induction failure in acute myeloid leukemia?
- Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation
- Correlation of TET2 SNP rs2454206 with improved survival in children with acute myeloid leukemia featuring intermediate‐risk cytogenetics
- Social preferences for health states associated with acute myeloid leukemia for patients undergoing treatment in the United Kingdom
- Universal monitoring of minimal residual disease in acute myeloid leukemia.
- Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission.
- Association of Second Allogeneic Hematopoietic Cell Transplant vs Donor Lymphocyte Infusion With Overall Survival in Patients With Acute Myeloid Leukemia Relapse
- FLAG salvage therapy combined with idarubicin in relapsed/refractory acute myeloid leukemia
- Hematopoietic stem cell transplantation for adult patients with isolated NPM1 mutated acute myeloid leukemia in first remission
- Myeloid malignancies with somatic GATA2 mutations can be associated with an immunodeficiency phenotype
- Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically
- Non‐acute promyelocytic leukemia variant, acute myeloid leukemia with translocation (11;17)
- Molecular characterization of acute myeloid leukemia patients who relapse more than 3 years after diagnosis: an exome sequencing study of 31 patients
- Allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia or myelodysplastic syndromes: myth and reality
- Akute myeloische Leukämie
- Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
- Deciphering the oncogenic network of PRC-2 loss guided leukemogenesis
Related papers
- Comparison of minimal residual disease (MRD) estimated by flow cytometry and by real-time quantitative PCR of Wilms tumor gene 1 (WT1) transcript expression in children with acute lymphoblastic leukemia.
- A simplified minimal residual disease polymerase chain reaction method at early treatment points can stratify children with acute lymphoblastic leukemia into good and poor outcome groups
- Next-Generation Sequencing for Minimal Residual Disease Surveillance in Acute Lymphoblastic Leukemia: An Update.
- Comparative analysis of flow cytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia
- EVALUATION OF RELATIONSHIP BETWEEN MINIMAL RESIDUAL DISEASE (MRD) AND RELAPSE IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) USING QUANTITATIVE FLUORESCENT PCR
- Detection of minimal residual disease in pediatric acute lymphoblastic leukemia
- Advances in the detection of minimal residual disease