Maspin: molecular mechanisms and therapeutic implications
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Summary
In this review, the regulation and roles of Maspin in normal and developmental biology are outlined while discussing novel evidence and emerging theories related to its functions in cancer.
- Type
- review
- Published
- 2012-07-01
- Cited by
- 103
- References
- 251
- OpenAlex
- https://openalex.org/W2091657079
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14698812
Keywords
Maspin, Context (archaeology), Angiogenesis, Suppressor, Cancer research
References
- Gamma-interferon induces an irreversible growth arrest in mid-G1 in mammary epithelial cells which correlates with a block in hyperphosphorylation of retinoblastoma.
- Expression of Maspin in Colon Cancers: Its Relationship with p53 Expression and Microvessel Density
- Prognostic significance of maspin expression in human gastric adenocarcinoma.
- Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer.
- Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas.
- mMaspin: The Mouse Homolog of a Human Tumor Suppressor Gene Inhibits Mammary Tumor Invasion and Motility
- Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.
- Mammary serine protease inhibitor inhibits epithelial growth factor‐induced epithelial‐mesenchymal transition of esophageal carcinoma cells
- Maspin is an angiogenesis inhibitor
- Maspin: synthesis by human cornea and regulation of in vitro stromal cell adhesion to extracellular matrix.
- Production, purification, and characterization of recombinant maspin proteins.
- Molecular Role(s) for Integrins in Human Melanoma Invasion
- The surface of prostate carcinoma DU145 cells mediates the inhibition of urokinase-type plasminogen activator by maspin.
- Temporal and spatial expression patterns for the tumor suppressor Maspin and its binding partner interferon regulatory factor 6 during breast development
- MnSOD Up-Regulates Maspin Tumor Suppressor Gene Expression in Human Breast and Prostate Cancer Cells
- Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins
- Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer.
- Identification of Phosphorylation Sites on Extracellular Corneal Epithelial Cell Maspin
- Elevated nuclear maspin expression is associated with microsatellite instability and high tumour grade in colorectal cancer
- Nitric oxide regulation of maspin expression in normal mammary epithelial and breast cancer cells.
Cited by
- RARs and microRNAs.
- Tumor suppressor maspin as a modulator of host immune response to cancer.
- A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma
- Biomarkers for pancreatic cancer : identification, validation and clinical application
- Mammary serine protease inhibitor and CD138 immunohistochemical expression in ovarian serous and clear cell carcinomas
- Serpin B5 is a CEA‐interacting biomarker for colorectal cancer
- Circulating DNA as biomarker in breast cancer
- miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin
- Maspin is not required for embryonic development or tumour suppression
- Expression of the tumour‐suppressor maspin in temporal bone carcinoma
- Tumor-suppressive Maspin Functions as a Reactive Oxygen Species Scavenger
- Fractal and image analysis of cytoskeletal changes in tumour cells due to the effects of maspin
- Nuclear maspin expression as a predictive marker for fluorouracil treatment response in colon cancer
- A hybrid computational model for the effects of maspin on cancer cell dynamics.
- Postoperative radiotherapy for laryngeal carcinoma: the prognostic role of subcellular Maspin expression.
- Elderly patients at higher risk of laryngeal carcinoma recurrence could be identified by a panel of two biomarkers (nm23-H1 and CD105) and pN+ status
- Identification of an Intrinsic Determinant Critical for Maspin Subcellular Localization and Function
- Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)
- Intracellular pigment epithelium-derived factor contributes to triglyceride degradation.
- The effects of non-inhibitory serpin maspin on cell migration using an artificial neural network
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