Flow cytometric study of T cell development in NOD mice reveals a deficiency in alphabetaTCR+CDR-CD8- thymocytes.
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Summary
It is suggested that the scarcity of NKT cells in NOD mice plays a role in the pathogenesis of IDDM because alphabeta+DN T cells, which are included among NK1+ T cells in C57BL/6 mice, produce large amounts of IL-4 on primary stimulation.
- Type
- article
- Published
- 1997-06-01
- Cited by
- 43
- References
- 0
- OpenAlex
- https://openalex.org/W2089110736
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25661342
Keywords
T-cell receptor, Nod, CD8, Immunology, NOD mice
References
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