Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.
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Summary
This regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate TH1 phenotype.
- Type
- article
- Published
- 1993-04-23
- Cited by
- 3,520
- References
- 38
- OpenAlex
- https://openalex.org/W1979514172
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26360798
Keywords
Listeria monocytogenes, Immune system, Biology, T cell, Acquired immune system
References
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- Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.
- IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
- Cloned L3T4+ T lymphocytes protect mice against Listeria monocytogenes by secreting IFN-gamma.
- Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.
- A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells.
- Effect of prostaglandin E2 (PGE2) on IL-3/granulocyte-macrophage colony-stimulating factor production by T helper cells. Mode of stimulation and presence of costimulation can determine response to PGE2.
- IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.
- Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice.
- IL-4 directs the development of Th2-like helper effectors.
- Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.
- Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.
- Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.
- Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
- The Importance of Th2 Cytokines in Protective Immunity to Nematodes
- A functional dichotomy in CD4+ T lymphocytes.
- Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.
- Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens
- Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.
Cited by
- Intraepithelial lymphocytes and the immune system.
- B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.
- T-Cell Subsets: Who does the polarizing?
- IL‐4 mRNA expression by peritoneal cells during episodes of peritonitis in patients on continuous ambulatory peritoneal dialysis
- High doses of interleukin‐12 inhibit the development of joint disease in DBA/1 mice immunized with type II collagen in complete Freund's adjuvant
- IL-12 Gene Therapy Using Direct Injection of Tumors with Genetically Engineered Autologous Fibroblasts. University of Pittsburgh, Pittsburgh, Pennsylvania
- Differential effects of interleukin-12 treatment on gene expression by allostimulated T cells from young and aged mice.
- Activation of natural killer cells by heat-killed Listeria monocytogenes requires additional signals from lymphoid cells.
- Development of th 1- or th 2-dominated immune responses: what about the polarizing signals?
- Phenotypic and functional characteristics of in vivo-induced interleukin-12-activated killer cells.
- Signal Transduction by Interleukin‐12 and Interleukin‐2
- Granulocyte-macrophage colony-stimulating factor and the immune system
- Recombinant Listeria monocytogenes as a live vaccine vehicle and a probe for studying cell‐mediated immunity
- Regulation of the IL‐12 receptor β2 subunit by soluble antigen and IL‐12 in vivo
- Immunoregulation during toxoplasmosis.
- Interleukin 12 Upregulates the Release of Vascular Permeability Factor by Peripheral Blood Mononuclear Cells from Patients with Lipoid Nephrosis
- Ovalbumin (OVA) and Mycobacterium tuberculosis bacilli cooperatively polarize anti-OVA T-helper (Th) cells toward a Th1-dominant phenotype and ameliorate murine tracheal eosinophilia.
- Immunological defense mechanisms in tuberculosis and MAC-infection.
- A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells1
- IL-4-Independent Inhibition of IL-12 Responsiveness During Leishmania amazonensis Infection1
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