The role of T lymphocytes in the pathogenesis of asthma.
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Summary
The efficacy of cyclosporin A and anti-CD4 treatment in patients with chronic severe asthma argues for continued T-cell involvement, but whether remodeling contributes to pathology inaccessible to anti-inflammatory treatment or T- cell immunotherapy will be an important future question.
- Type
- review
- Published
- 2003-03-01
- Cited by
- 636
- References
- 145
- Access
- Open access
- OpenAlex
- https://openalex.org/W2086782209
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22908314
Keywords
Immunology, Immunotherapy, Asthma, T cell, GATA3
References
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- Expression of Chemokine Receptors by Lung T Cells from Normal and Asthmatic Subjects1
- A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation
- The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man.
- A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5.
- ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses
- Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids.
- New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-251
- IL-11 Selectively Inhibits Aeroallergen-Induced Pulmonary Eosinophilia and Th2 Cytokine Production1
- IgE versus IgG4 production can be differentially regulated by IL-10.
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- The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.
- Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity [published erratum appears in J Exp Med 1997 May 5;185(9):1715]
- A novel transcription factor, T-bet, directs Th1 lineage commitment.
Cited by
- Cytokines and cytokine-specific therapy in asthma.
- Therapeutic immunomodulation of allergic lung disease using regulatory dendritic cells in a mouse model of asthma
- Immunomodulation
- Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release
- the Relationship between Vitamin D Statuses and Young Adult Women Asthma
- Interleukin-4 induced leukocyte differentiation
- Búsqueda de perfiles moleculares diferenciales entre tolerancia y sensibilización en la respuesta alérgica
- Protein-protein interaction network analysis of children atopic asthma.
- Allergen-specific immunotherapy: towards combination vaccines for allergic and infectious diseases.
- Anti-Interleukin-5 Monoclonal Antibodies
- Anti-dermatitis Effects of KamiCheongsimyeonjatang on GATA-3 Regulation in NC/Nga Mouse
- Bronchial Challenges in Airways Disease
- Studies on the effect of cysteinyl leukotrienes on human T cell differentiation and function
- Thymic Stromal Lymphopoietin: Expression and Secretion by Airway Epithelium as a Function of Genotype
- SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model.
- The Properties of Circulating Fibrocytes in Severe Asthma
- Interplay of T Helper 17 Cells with CD4+CD25high FOXP3+ Tregs in Regulation of Allergic Asthma in Pediatric Patients
- House dust mite allergy
- The role of T lymphocytes in asthma.
- IL-13 Regulates the Immune Response to Inhaled Antigens1
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