A receptor-mediated pathway for cholesterol homeostasis.
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Summary
The approach was to apply the techniques of cell culture to unravel the postulated regulatory defect in FH, which led to the discovery of a cell surface receptor for a plasma cholesterol transport protein called low density lipoprotein (LDL) and to the elucidation of the mechanism by which this receptor mediates feedback control of cholesterol synthesis.
- Type
- review
- Published
- 1986-04-04
- Cited by
- 5,631
- References
- 157
- OpenAlex
- https://openalex.org/W2084744450
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7027904
Keywords
Homeostasis, Receptor, Chemistry, Cholesterol, Cell biology
References
- 125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts
- Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
- Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts
- Commentary. Lysosomotropic agents.
- Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.
- Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.
- Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.
- The LDL receptor and HMG-CoA reductase--two membrane molecules that regulate cholesterol homeostasis.
- Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex.
- Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.
- Characterization of the sinusoidal transport process responsible for uptake of chylomicrons by the liver.
- Lipid metabolism in tissue culture cells.
- Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.
- Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.
- Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.
- Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
- Functional segregation of hepatic receptors for asialoglycoproteins during endocytosis.
- Cholesterol biosynthesis in preparations of liver from normal, fasting, x-irradiated, cholesterol-fed, triton, or delta 4-cholesten-3-one-treated rats.
- Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts.
- Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.
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- Neural Stem Cell Grafts and the Influence of Apolipoprotein E in a Mouse Model of Global Ischaemia
- Phosphoinositide and calcium signalling responses in smooth muscle cells: comparison between lipoproteins, Ang II, and PDGF.
- Serum lipoprotein profile in the Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency
- Modulation of infant formula fat profile alters the low-density lipoprotein/high-density lipoprotein ratio and plasma fatty acid distribution relative to those with breast-feeding.
- Hepatic metabolism of cholesterol in Crohn's disease. Effect of partial resection of ileum.
- The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor
- Differences in Lipoprotein Subfraction Composition and Distribution Between Type I Diabetic Men and Control Subjects
- Structural properties of the heparin-binding domains of human apolipoprotein E.
- Diagnosis and management of familial dyslipoproteinemia in children and adolescents.
- Pancreatic cholesterol esterases. 3. Kinetic characterization of cholesterol ester resynthesis by the pancreatic cholesterol esterases.
- Role of eicosanoids and the cytokine network in transmembrane signaling in vascular cells.
- Type C Niemann-Pick disease: dimethyl sulfoxide moderates abnormal LDL-cholesterol processing in mutant fibroblasts.
- The Role of Vitamin E and Carotenoids in Preventing Oxidation of Low Density Lipoproteins a
- Immunotoxins, ligand-toxin conjugates and molecular targeting.
- The Lipoprotein Receptor Concept
- Identification of macrophages and smooth muscle cells with monoclonal antibodies in the human atherosclerotic plaque
- Circulatory and Degenerative Dementias
- Cholesterol is necessary for triacylglycerol-phospholipid emulsions to mimic the metabolism of lipoproteins.
- Editorial comment Atherosclerosis: cell biology and lipoproteins
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