Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.
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Summary
It is concluded that: 1) the serine- and threonine-rich region of the LDL receptor is the site for addition of clustered O-linked carbohydrates; 2) the receptor contains a small number of isolated chains of O- linked carbohydrates in addition to the clustered chains; and 3) the clustered O -linked carbohydrates are not essential for LDL receptor function in cultured hamster fibroblasts.
- Type
- article
- Published
- 1986-02-25
- Cited by
- 156
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W25867637
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24389713
Keywords
Threonine, Serine, Complementary DNA, Biochemistry, LDL receptor
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