β‐catenin is a target for the ubiquitin–proteasome pathway
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Summary
It is shown that ubiquitination of β‐catenin is greatly reduced in Wnt‐expressing cells, providing the first evidence that the ubiquitin–proteasome degradation pathway may act downstream of GSK3β in the regulation ofβ‐ catenin.
- Type
- article
- Published
- 1997-07-01
- Cited by
- 2,430
- References
- 51
- OpenAlex
- https://openalex.org/W2081985759
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9561740
Keywords
Biology, Ubiquitin, Proteasome, Catenin, Deubiquitinating enzyme
References
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- Not just glue: cell-cell junctions as cellular signaling centers.
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- Cadherins and catenins in development.
Cited by
- GATA transcription factors in the developing reproductive system.
- c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover.
- A NOVEL CLASS OF IMMUNOPROTEASOME CATALYTIC SUBUNIT LMP2 INHIBITOR AND ITS THERAPEUTIC POTENTIALS IN CANCER
- APC and β-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers
- Wnt signaling function in Alzheimer's disease.
- A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.
- Tumor Suppressor Pten Inhibits Nuclear Accumulation of β-Catenin and T Cell/Lymphoid Enhancer Factor 1–Mediated Transcriptional Activation
- Different patterns of β‐catenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome
- E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity
- Disulfide Bond Assignments of Secreted Frizzled-related Protein-1 Provide Insights about Frizzled Homology and Netrin Modules*
- Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
- Wnt signaling during BMP‐2 stimulation of mesenchymal chondrogenesis
- Stimulation of Cdx1 by oncogenic β‐catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein
- Gene expression profiling reveals a highly specialized genetic program of plasma cells.
- Adherens junctions and cancer.
- Tumor formation is correlated with expression of β‐catenin‐accumulated crypts in azoxymethane‐induced colon carcinogenesis in mice
- Fibroblast growth factor-2 induces osteoblast survival through a phosphatidylinositol 3-kinase-dependent, -beta-catenin-independent signaling pathway.
- Negative regulators of cardiac hypertrophy.
- Multiple functions for the cadherin/catenin complex during neuronal development.
- Roles of SCF and VHL ubiquitin ligases in regulation of cell growth.
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