How do microRNAs regulate gene expression?
Explore this paper's citation graph
Summary
This review focuses on understanding how miRNA repression is operating in light of findings and the questions that still remain on the mechanism of miRNA-mediated translational repression.
- Type
- review
- Published
- 2008-12-01
- Cited by
- 658
- References
- 101
- OpenAlex
- https://openalex.org/W2080327351
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23107796
Keywords
microRNA, Gene silencing, Psychological repression, Untranslated region, Translation (biology)
References
- Short RNAs repress translation after initiation in mammalian cells.
- Human let-7a miRNA blocks protein production on actively translating polyribosomes
- Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation
- Translational control of gene expression
- The role of mRNA competition in regulating translation. I. Demonstration of competition in vivo.
- Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry
- Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies
- Global control of gene expression in yeast by the Ccr4-Not complex.
- Thymidine kinase synthesis is repressed in nonreplicating muscle cells by a translational mechanism that does not affect the polysomal distribution of thymidine kinase mRNA.
- Disruption of GW bodies impairs mammalian RNA interference
- Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz
- Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
- Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
- Dissociation of mammalian polyribosomes into subunits by puromycin.
- Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
- The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene
- Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity
- The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules
- MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
- Principles of MicroRNA–Target Recognition
Cited by
- Translational control of gene expression from transcripts to transcriptomes.
- miRNAs in cancer: approaches, aetiology, diagnostics and therapy.
- Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells
- Neuronal Expression of Splice Variants of “Glial” Glutamate Transporters in Brains Afflicted by Alzheimer’s Disease: Unmasking an Intrinsic Neuronal Property
- MicroRNA in erythrocytes.
- Gene Expression Analysis of Forskolin Treated Basilar Papillae Identifies MicroRNA181a as a Mediator of Proliferation
- Basic and simple mathematical model of coupled transcription, translation and degradation
- MicroRNAs and the Warburg Effect: new players in an old arena.
- MicroRNA‑21 regulation of the progression of viral myocarditis to dilated cardiomyopathy.
- The expression profiles of microRNAs in Kaposi’s sarcoma
- Comprehensive Expression Profiling and Functional Network Analysis of Porphyra-334, One Mycosporine-Like Amino Acid (MAA), in Human Keratinocyte Exposed with UV-radiation
- Noncoding miRNAs as key controllers of pancreatic β-cell functions
- Ten Years of Progress in GW/P Body Research
- Towards the identification of regulatory networks using statistical and information theoretical methods on the mammalian transcriptome
- Generation and Bioinformatic Analysis of Synthetic Ago HITS-CLIP Data
- Gene expression in Rhipicephalus (Boophilus) microplus: Identification of tick antigens and investigation of the tick RNA interference pathway
- Role and regulatory mechanisms of heat shock factor 2
- Role of CPEB in Senescence and Inflammation: A Dissertation
- Functions of miR-1 and miR-133a during the postnatal development of masseter and gastrocnemius muscles
- Comparison of the pharmacokinetic and pharmacodynamic profiles of resveratrol at dietary and pharmacological doses
Related papers
- The composition of untranslated regions in Trypanosoma cruzi genes.
- Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon.
- 食管癌细胞SHEEC中NGAL基因5’—UTR和3’—UTR的克隆与鉴定
- Constructing series of clones with different functional regions deletion of PEPV 5′Untranslated region and sequence analysis
- 3′ UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblasts
- 3′untranslated regions: regulation at the end of the road
- Progress in the Studies on Function of 3' Untranslated Region on Post-transcriptional Level