Rho and Rac take center stage.
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Summary
This work will describe how the activity of Rho proteins is regulated downstream from growth factor receptors and cell adhesion molecules by guanine nucleotide exchange factors and GTPase activating proteins.
- Type
- review
- Published
- 2004-01-23
- Cited by
- 1,870
- References
- 121
- Access
- Open access
- OpenAlex
- https://openalex.org/W2077080652
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2838904
Keywords
Crosstalk, Biology, Guanine nucleotide exchange factor, Cell biology, GTPase
References
- Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks.
- Cadherin Engagement Inhibits RhoA via p190RhoGAP*
- Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
- Filamins as integrators of cell mechanics and signalling
- EPS8 and E3B1 transduce signals from Ras to Rac
- Identification of a novel Rac1‐interacting protein involved in membrane ruffling.
- Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading
- Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins.
- IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
- Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.
- Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration
- Role of citron kinase as a target of the small GTPase Rho in cytokinesis
- The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
- RhoB, Not RhoA, Represses the Transcription of the Transforming Growth Factor β Type II Receptor by a Mechanism Involving Activator Protein 1*
- The Rho GTPase family: a Racs to Wrchs story.
- The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia
- Rac Regulates Integrin-Mediated Spreading and Increased Adhesion of T Lymphocytes
- Growth-regulated expression of rhoG, a new member of the ras homolog gene family
- Genomic analysis of metastasis reveals an essential role for RhoC
- Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB.
Cited by
- Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy
- Signaling endosomes and growth cone motility in axon regeneration.
- Smooth Muscle Actin Determines Mechanical Force-induced p38 Activation*
- Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors.
- RalA and RalB: antagonistic relatives in cancer cell migration.
- Regulation of epithelial tubule formation by Rho family GTPases.
- Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1.
- Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells.
- Signaling mechanisms utilized by antigen receptors and integrins: common intermediates, different outcomes?
- Albumin Activation of NAD(P)H Oxidase Activity Is Mediated via Rac1 in Proximal Tubule Cells
- The mineralocorticoid receptor in endothelial physiology and disease: novel concepts in the understanding of erectile dysfunction.
- The dioxin receptor regulates the constitutive expression of the vav3 proto-oncogene and modulates cell shape and adhesion.
- Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis
- The burden of age-related macular degeneration: a value-based analysis
- Geranylgeranyl Diphosphate Synthase: An Emerging Therapeutic Target
- Modulation of Rho GTPases and the actin cytoskeleton by YopT of Yersinia.
- Thy-1-mediated Cell -Cell Contact Induces Astrocyte Migration through the Engagement of αVβ3 Integrin and Syndecan-4
- Rho small GTPase regulates the stability of individual focal adhesions: a FRET-based visualization of GDP/GTP exchange on small GTPases
- An In Vitro Kinase Assay to Assess Rac1 Phosphorylation by ERK.
- The role of PI3K in Ephrin-A1 induced cell retraction
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