Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
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Summary
It is shown that the perceived central role for IL-12 in autoimmune inflammation, specifically in the brain, has been misinterpreted and that IL-23, and not IL- 12, is the critical factor in this response.
- Type
- article
- Published
- 2003-02-13
- Cited by
- 3,134
- References
- 29
- OpenAlex
- https://openalex.org/W2076889715
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4380302
Keywords
Cytokine, Biology, Immune system, Immunology, Interleukin 23
References
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- Impaired Pulmonary Host Defense in Mice Lacking Expression of the CXC Chemokine Lungkine1
- A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1
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- Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection
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- T‐lymphocyte entry into the central nervous system
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- Regulation of Experimental Autoimmune Encephalomyelitis by Interleukin‐12
- Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.
- IL-12 in autoimmunity.
- Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Cited by
- IL-1 regulates the IL-23 response to wheat gliadin, the etiologic agent of Celiac Disease
- Wolbachia endosymbiont of Onchocerca volvulus: driver of immunopathology and target for therapy
- Genetics of Multiple Sclerosis
- Estudio del rol de la vía de PD-1 sobre la respuesta inmune de células Nk y de los mecanismos inmunológicos inducidos por las células Th9 frente a la infección por M. tuberculosis
- Galectins and neuroinflammation.
- Enhanced pro-inflammatory cytokine production in Galphai2-deficient mice on colitis prone and colitis resistant 129Sv genetic backgrounds.
- IL-12p40 and IL-18 Modulate Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection1
- IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.
- IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production
- Vaccination against IL‐17 suppresses autoimmune arthritis and encephalomyelitis
- IL-17 family cytokines and the expanding diversity of effector T cell lineages.
- The biological and clinical significance of the maternal immune response to fetal antigens
- Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer
- Retinoid signals and Th17-mediated pathology.
- Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
- IL-17 inhibits human Th1 differentiation through IL-12R beta 2 downregulation.
- Disturbed regulatory T cell homeostasis in multiple sclerosis.
- Th17 cells: positive or negative role in tumor?
- Xuebijing protects against lipopolysaccharide-induced lung injury in rabbits
- Transforming Growth Factor Beta Is a Major Regulator of Human Neonatal Immune Responses following Respiratory Syncytial Virus Infection
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