Antibody‐targeted superantigen therapy induces tumor‐infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma
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Summary
It is demonstrated that antibody‐superantigen proteins efficiently recruit tumor‐infiltrating lymphocytes actively producing a variety of cytokines likely to be essential for the therapeutic effects observed in the model, and encourages clinical evaluation of antibody‐targeted superantigens.
- Type
- article
- Published
- 1996-01-01
- Cited by
- 71
- References
- 46
- OpenAlex
- https://openalex.org/W2075956457
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13423549
Keywords
Superantigen, Biology, Apoptosis, Cytokine, Colon carcinoma
References
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- Epithelial apoptosis
- Cross-presentation of cell-associated antigens by dendritic cells.
- Dendritic cells for the induction of EBV immunity.
- Techniques in Quantification and Localization of Gene Expression
- Genetically engineered superantigens as tolerable antitumor agents.
- Preparation and activity of conjugate of monoclonal antibody HAb18 against hepatoma F(ab')(2) fragment and staphylococcal enterotoxin A.
- Perforin and IFN-gamma are involved in the antitumor effects of antibody-targeted superantigens.
- SCID mouse models to study human cancer pathogenesis and approaches to therapy: potential, limitations, and future directions.
- Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
- A novel anticancer approach: SEA-anchored tumor cells expressing heat shock protein 70 onto the surface elicit strong anticancer efficacy.
- Positive selection of thymocytes: the long and winding road.
- Preclinical evaluation of superantigen (staphylococcal enterotoxin B) in the intravesical immunotherapy of superficial bladder cancer
- Immunologic changes in healthy probands and HIV infected patients after oral administration of Staphylococcus aureus 12c: a pilot study
- Combining tumor-targeted superantigens with interferon-alpha results in synergistic anti-tumor effects.
- Humanized antibodies as potential therapeutic drugs.
- Identification of the antigenic epitopes in staphylococcal enterotoxins A and E and design of a superantigen for human cancer therapy.
- Overview of clinical trials employing antibody-targeted superantigens.
- Characterization of the progressive skin disease and inflammatory cell infiltrate in mice with inhibited NF-kappaB signaling.
- DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes
- Diagnostic and therapeutic applications of monoclonal antibodies in colorectal cancer
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