Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
Explore this paper's citation graph
Summary
It is shown that human dendritic cells, but not macrophages, efficiently present antigen derived from apoptotic cells, stimulating class I-restricted CD8+ CTLs, suggesting a mechanism by which potent APCs acquire antigens from tumours, transplants, infected cells, or even self-tissue, for stimulation or tolerization of C TLs.
- Type
- article
- Published
- 1998-03-05
- Cited by
- 2,607
- References
- 31
- OpenAlex
- https://openalex.org/W1561591381
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4423262
Keywords
Cytotoxic T cell, Antigen, Major histocompatibility complex, Priming (agriculture), MHC class I
References
- Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.
- A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides.
- Constitutive class I-restricted exogenous presentation of self antigens in vivo
- The roles of interdigitating cells and natural killer cells in the rapid rejection of allogeneic lymphocytes
- Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells
- Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
- Hairy cell leukemia cells express CD1A antigen
- Programmed cell death (apoptosis) in human monocytes infected by influenza A virus.
- Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability.
- Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens.
- The distinctive features of influenza virus infection of dendritic cells.
- An in situ immunogold method applied to the identification of plasma membrane-associated antigens of skin-infiltrating cells.
- Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood.
- Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2
- Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
- Antibody‐targeted superantigen therapy induces tumor‐infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma
- A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules
- Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.
- Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo
- Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells
Cited by
- Antitumor activities of human dendritic cells derived from peripheral and cord blood.
- Regulation of memory CD8 T cell differentiation
- Transfected human dendritic cells as cancer vaccines
- Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA
- Antigen presenting cells integrate opposing signals from CD4+ and CD8+ regulatory T lymphocytes to arbitrate the outcomes of immune responses.
- T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal.
- Salmonella-Induced Apoptosis of Infected Macrophages Results in Presentation of a Bacteria-Encoded Antigen after Uptake by Bystander Dendritic Cells
- Dendritic Cell/Peptide Cancer Vaccines: Clinical Responsiveness and Epitope Spreading
- Successful reversal of recalcitrant hepatic allograft rejection by photopheresis
- CD40 ligation for immunotherapy of solid tumours.
- Immunology 102 at poxvirus U: avoiding apoptosis.
- CD14 and apoptosis
- Immunity against solid tumors?
- A role for CD36 in the regulation of dendritic cell function
- Identification and characterization of genes with specific expression in dendritic cells
- Apoptosis of skeletal muscle cells and the pathogenesis of Myositis: A perspective
- Influenza Virus NS1 Protein Induces Apoptosis in Cultured Cells
- Epidermal Powder Immunization Induces both Cytotoxic T-Lymphocyte and Antibody Responses to Protein Antigens of Influenza and Hepatitis B Viruses
- An immune hypothesis of sexual orientation.
- Combination of γ‐irradiation and dendritic cell administration induces a potent antitumor response in tumor‐bearing mice: Approach to treatment of advanced stage cancer
Related papers
- Expression of CD1 and class I MHC antigens by human thymocytes.
- Proteasomes, TAP and ERAAP control CD4+ TH cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens
- Viral immune evasion: Lessons in MHC class I antigen presentation.
- CD1--a new paradigm for antigen presentation and T cell activation.
- Alternative pathways for MHC class I presentation: a new function for autophagy
- Langerhans cells of human skin are the natural antigen‐presenting cells for CD1c antigen presentation
- Principles of MHC class I-mediated antigen presentation and T cell selection.
- Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells
- Antigen processing and presentation by epidermal Langerhans cells. Induction of immunity or unresponsiveness.