Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

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Summary

It is shown that human dendritic cells, but not macrophages, efficiently present antigen derived from apoptotic cells, stimulating class I-restricted CD8+ CTLs, suggesting a mechanism by which potent APCs acquire antigens from tumours, transplants, infected cells, or even self-tissue, for stimulation or tolerization of C TLs.

Type
article
Published
1998-03-05
Cited by
2,607
References
31

Keywords

Cytotoxic T cell, Antigen, Major histocompatibility complex, Priming (agriculture), MHC class I

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