NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
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Summary
A role is proposed for miR-146 in control of Toll-like receptor and cytokine signaling through a negative feedback regulation loop involving down-regulation of IL-1 receptor-associated kinase 1 and TNF receptor- associated factor 6 protein levels.
- Type
- article
- Published
- 2006-08-15
- Cited by
- 4,048
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W2075860675
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12056148
Keywords
Biology, Cell biology, Innate immune system, microRNA, Signal transduction
References
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- Toll-like receptor signalling
- Negative regulation of Toll-like receptor-mediated immune responses
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- The Microprocessor complex mediates the genesis of microRNAs
- Combinatorial microRNA target predictions
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- A microRNA polycistron as a potential human oncogene
- Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells.
Cited by
- Inhibitory RNA Molecules in Immunotherapy for Cancer
- Functions of mammalian microRNA in innate immunity to microbial infection
- RNAi and Cellular miRNAs in Infections by Mammalian Viruses
- The microRNA regulatory network in normal- and HTLV-1-transformed T cells.
- Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics.
- Human cytomegalovirus microRNAs.
- In vivo profile of the human leukocyte microRNA response to endotoxemia.
- MicroRNA expression profiles predictive of human renal allograft status
- NF‐κB activation stimulates osteogenic differentiation of mesenchymal stem cells derived from human adipose tissue by increasing TAZ expression
- Interleukins 1α and 1β secreted by some melanoma cell lines strongly reduce expression of MITF‐M and melanocyte differentiation antigens
- The role of microRNAs in the control and mechanism of action of IL-10.
- miRNAs and rheumatoid arthritis - promising novel biomarkers.
- Evidence for a role of microRNA-146a in the pathogenesis of systemic lupus erythematosus with atherosclerosis: comment on the article by Li et al.
- Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression
- Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjögren's syndrome.
- Dynamic Modulation of Thymic MicroRNAs in Response to Stress
- Micro-RNAs as regulators and possible diagnostic bio-markers in inflammatory bowel disease.
- Inflammation, chronic obstructive pulmonary disease and aging
- microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population.
- Differential regulation of miR-21 and miR-146a by Epstein–Barr virus-encoded EBNA2
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