Statins and cancer: current and future prospects.
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Summary
The preclinical results strongly suggest that the use of statins combined with other chemotherapeutics to increase the effectiveness of cancer treatments could be a promising new strategy for the treatment of certain tumor types.
- Type
- review
- Published
- 2012-11-01
- Cited by
- 182
- References
- 166
- OpenAlex
- https://openalex.org/W2073131803
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25532429
Keywords
Medicine, Cancer, Statin, HMG-CoA reductase, Pharmacology
References
- Phase II Study of High-Dose Lovastatin in Patients with Advanced Gastric Adenocarcinoma
- Cell-Cycle Gene Expression in Lovastatin-Induced Medulloblastoma Apoptosis
- Lovastatin-induced apoptosis in human melanoma cell lines
- Periprocedural Myocardial Infarction: Review and Classification
- Class-specific pro-apoptotic effect of statins on human vascular endothelial cells
- Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach.
- Statins and gastric cancer risk.
- Pleiotropic Effects of Statins
- Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells
- Statin use and the risk of prostate cancer: A metaanalysis of 6 randomized clinical trials and 13 observational studies
- Lovastatin potentiates antitumor activity and attenuates cardiotoxicity of doxorubicin in three tumor models in mice.
- Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide
- Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux.
- Up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in left-sided human colon cancer.
- Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells.
- Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells.
- Simvastatin plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) as first-line chemotherapy in metastatic colorectal patients: a multicenter phase II study
- Simvastatin induces apoptosis in human breast cancer cells: p53 and estrogen receptor independent pathway requiring signalling through JNK.
- Statins and cancer: A systematic review and meta-analysis.
- Comparative evaluation of the effects of statins on human stem and cancer cells in vitro.
Cited by
- Chemoprevention of skin melanoma: facts and myths
- Melittin-induced long non-coding RNA NONHSAT105177 inhibits proliferation and migration of pancreatic ductal adenocarcinoma
- HIGH DOSE SIMVASTATIN AS A POTENTIAL ANTICANCER THERAPY IN LEUKEMIA PATIENTS
- The effect of statins on cancer cells—review
- Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link
- A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors
- Inhibition of lung carcinogenesis by polymethoxyflavones
- Cytotoxic Effect of Fluvastatin on MCF-7 Cells Possibly Through a Reduction of the mRNA Expression Levels of SGK1 and CAV1
- European Code against Cancer 4th Edition: Medical exposures, including hormone therapy, and cancer.
- Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation
- The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann Pick Type C1 mutation and altered integrin trafficking
- Exploitation of pleiotropic actions of statins by using tumour-targeted delivery systems
- Inhibition of Autophagy Potentiates Atorvastatin-Induced Apoptotic Cell Death in Human Bladder Cancer Cells in Vitro
- Tropical cattle methane emissions: the role of natural statins supplementation
- Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells.
- Anti-Cancer Potential of MAPK Pathway Inhibition in Paragangliomas–Effect of Different Statins on Mouse Pheochromocytoma Cells
- Combination of 13-Cis retinoic acid and lovastatin: marked antitumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice.
- The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination
- Promising anti-leukemic activity of atorvastatin.
- New strategies for the treatment of ovarian cancer.
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