New strategies for the treatment of ovarian cancer.
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Summary
The potential for use of BH3 (Bcl-2 homology) mimetics, autotaxin inhibitors and statins to treat ovarian cancer is reviewed, and pre-clinical studies have identified several potential new therapeutic strategies.
- Type
- review
- Published
- 2014-02-01
- Cited by
- 6
- References
- 45
- OpenAlex
- https://openalex.org/W1977782643
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42431152
Keywords
Ovarian cancer, Autotaxin, Medicine, Poly ADP ribose polymerase, Chemotherapy
References
- Phase II Study of High-Dose Lovastatin in Patients with Advanced Gastric Adenocarcinoma
- Carboplatin and paclitaxel in ovarian carcinoma: a phase I study of the Gynecologic Oncology Group.
- Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells.
- Dysregulation of the mevalonate pathway promotes transformation
- Phase II study of metronomic chemotherapy with thalidomide, carboplatin-vincristine-fluvastatin in the treatment of brain stem tumors in children.
- Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells.
- Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease.
- Making the best of PARP inhibitors in ovarian cancer
- High dose Simvastatin does not reverse resistance to Vincristine, Adriamycin, and Dexamethasone (VAD) in Myeloma
- Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases
- Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells.
- Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression
- Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
- Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis
- Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
- Statin Induces Apoptosis and Cell Growth Arrest in Prostate Cancer Cells
- Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum, and survival.
- DISTINCT AUTOPHAGOSOMAL-LYSOSOMAL FUSION MECHANISM REVEALED BY THAPSIGARGIN-INDUCED AUTOPHAGY ARREST
- Benzyl and Naphthalene-Methyl Phosphonic Acid Inhibitors of Autotaxin with Anti-invasive and Anti-metastatic Actions
- Differences in antitumor effects of various statins on human pancreatic cancer
Cited by
- Paclitaxel targets VEGF-mediated angiogenesis in ovarian cancer treatment.
- Statin as a Combined Therapy for Advanced-Stage Ovarian Cancer: A Propensity Score Matched Analysis
- Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells
- ABT-737 and pictilisib synergistically enhance pitavastatin-induced apoptosis in ovarian cancer cells.
- Statin use is associated with improved survival in ovarian cancer: A retrospective population-based study
- MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis
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