TRF2 protects human telomeres from end-to-end fusions.
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Summary
It is shown that the human telomeric protein TRF2 plays a key role in the protective activity of telomeres, and the results raise the possibility that chromosome end fusions and senescence in primary human cells may be caused by loss byTRF2 from shortenedtelomeres.
- Type
- article
- Published
- 1998-02-06
- Cited by
- 1,768
- References
- 67
- Access
- Open access
- OpenAlex
- https://openalex.org/W2072744580
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15976686
Keywords
Telomere, Biology, Shelterin, Metaphase, Cell biology
References
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- Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA.
- Cold spring harbor.
- TRF1, a mammalian telomeric protein.
- Telomerase activity in normal and malignant hematopoietic cells.
Cited by
- Processing of Alternative DNA Structures in the Human Telomere
- DNA G-Quadruplexes, Telomere-Specific Proteins and Telomere-Associated Enzymes as Potential Targets for New Anticancer Drugs
- Telomerase activation: one step on the road to cancer?
- Telomeres and telomerase: more than the end of the line
- Identification and Characterization of a Bovine Sperm Protein That Binds Specifically to Single-Stranded Telomeric Deoxyribonucleic Acid1
- In Vitro Properties of the Conserved Mammalian Protein hnRNP D Suggest a Role in Telomere Maintenance
- Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.
- A Trypanosoma brucei Protein Complex That Binds G-overhangs and Co-purifies with Telomerase Activity*
- Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
- Immunosenescence phenotypes in the telomerase knockout mouse
- Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells.
- Vascular cell senescence and vascular aging.
- XPF/ERCC4 and ERCC1: their products and biological roles.
- Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines
- DNA breaks promote genomic instability by impeding proper chromosome segregation.
- Inhibition of 6A8 alpha-mannosidase gene expression resulted in telomere length shortening in nasopharyngeal carcinoma cell CNE-2L2.
- Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands
- The signals and pathways activating cellular senescence.
- Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging
- Telomeres and telomerase: from basic research to clinical applications.
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