PedCheck: a program for identification of genotype incompatibilities in linkage analysis.
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Summary
Four error-checking algorithms are implemented in a new computer program, PedCheck, which will assist researchers in identifying all Mendelian inconsistencies in pedigree data and will provide them with useful and detailed diagnostic information to help resolve the errors.
- Type
- article
- Published
- 1998-07-01
- Cited by
- 2,184
- References
- 18
- Access
- Open access
- OpenAlex
- https://openalex.org/W2072038834
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23874108
Keywords
Computer science, Identification (biology), Pedigree chart, Statistic, Linkage (software)
References
- Evaluating pedigree data. I. The estimation of pedigree error in the presence of marker mistyping.
- An algorithm for automatic genotype elimination.
- Genetic mapping and DNA sequencing
- Relationship Estimation in Affected Sib Pair Analysis of Late-Onset Diseases
- Error detection for genetic data, using likelihood methods.
- Identifying marker typing incompatibilities in linkage analysis.
- Construction of human linkage maps: Likelihood calculations for multilocus linkage analysis
- Easy calculations of lod scores and genetic risks on small computers.
- Programs for pedigree analysis: Mendel, Fisher, and dGene
- Detecting marker inconsistencies in human gene mapping.
- The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set–recoding and fuzzy inheritance
- Evaluating pedigree data. II. Identifying the cause of error in families with inconsistencies.
- Efficient computation of lod scores: genotype elimination, genotype redefinition, and hybrid maximum likelihood algorithms
- Strategies for multilocus linkage analysis in humans.
- A test statistic to detect errors in sib-pair relationships.
- Accurate inference of relationships in sib-pair linkage studies.
- Relationship Estimation in Affected Sib Pair Analysis of Late-Onset Diseases
Cited by
- Genome-Wide Linkage Analysis Reveals Evidence of Multiple Regions That Influence Variation in Plasma Lipid and Apolipoprotein Levels Associated With Risk of Coronary Heart Disease
- Coincident Linkage of Fasting Plasma Insulin and Blood Pressure to Chromosome 7q in Hypertensive Hispanic Families
- Detecting Population Outliers and Null Alleles in Linkage Data: Application to GAW12 Asthma Studies
- Susceptibility loci for atopic dermatitis on chromosomes 3, 13, 15, 17 and 18 in a Swedish population.
- A Genome-Wide Scan for Urinary Albumin Excretion in Hypertensive Families
- Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease.
- Investigating the genetics of primary open-angle glaucoma in Tasmania
- Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics
- A Genome-Wide Scan for Carotid Artery Intima-Media Thickness: The Mexican-American Coronary Artery Disease Family Study
- A male-specific quantitative trait locus on 1p21 controlling human stature
- Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine‐related trait and cocaine‐induced paranoia
- Genes outside The Hla Region affecting Susceptibility to Type 1 Diabetes - The Role of Iddm2 and Iddm9 in the Finnish Population
- Factors affecting statistical power in the detection of genetic association.
- Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study.
- Linkage but Not Association of Calpain-10 to Type 2 Diabetes Replicated in Northern Sweden
- Integrating Molecular Genetics Analyses Into Clinical Research
- IL6 -174 G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil.
- Genomewide scan for nonsyndromic cleft lip and palate in multigenerational Indian families reveals significant evidence of linkage at 13q33.1-34.
- PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not.
- Genomewide Linkage Scan for Combined Obesity Phenotypes using Principal Component Analysis
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