PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not.
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Summary
The results implicate PTPN22 in mediating susceptibility to generalized vitiligo and associated autoimmune diseases, but do not support a role for CTLA4.
- Type
- article
- Published
- 2008-07-01
- Cited by
- 76
- References
- 50
- OpenAlex
- https://openalex.org/W18200060
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42649815
Keywords
Computer science
References
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- PTPN22: setting thresholds for autoimmunity.
- Difference in clinical features and HLA antigens between familial and non‐familial vitiligo of non‐segmental type
- A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
- Genetic nature of vitiligo.
Cited by
- Systemic lupus erythematosus and rheumatoid arthritis : analyses of candidate genes involved in immune functions, for susceptibility and severity
- Lack of association between cytotoxic T-lymphocyte antigen-4+49A/G polymorphism and psoriasis and vitiligo: A meta-analysis of case-control studies.
- Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity
- Deciphering the link between PTPN22 and autoimmunity
- Setting priorities and reducing uncertainties for the treatment of vitiligo
- An Investigation of Autoantibodies against Tyrosine Hydroxylase in Patients with Vitiligo
- Vitiligo - Part 1
- Déterminisme des pathologies auto-immunes : facteurs génétiques et environnementaux
- Genetic susceptibility to vitiligo: Recent progress from genome-wide association studies
- Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs.
- Shared Genetic Relationships Underlying Generalized Vitiligo and Autoimmune Thyroid Disease
- CTLA4 and generalized vitiligo: two genetic association studies and a meta-analysis of published data
- +49G > A polymorphism in the cytotoxic T-lymphocyte antigen-4 gene increases susceptibility to hepatitis B-related hepatocellular carcinoma in a male Chinese population.
- Association study between keratinocyte‐derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor
- The CTLA-4 +49A/G, CT60A/G and PTPN22 1858 C/T polymorphisms and susceptibility to vitiligo: a meta-analysis
- The Protein Tyrosine Phosphatase Non-Receptor Type 22 C1858T Polymorphism Is a Joint Susceptibility Locus for Immunthyroiditis and Autoimmune Diabetes
- Modern vitiligo genetics sheds new light on an ancient disease
- Lack of Association between PTPN22 Gene +1858 C>T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population
- Role of Cytokines in Systemic Lupus Erythematosus: Recent Progress from GWAS and Sequencing
- Genetic Variation of Promoter Sequence Modulates XBP1 Expression and Genetic Risk for Vitiligo
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