The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
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Summary
The data suggest that the Tim-3–galectin-9 pathway may have evolved to ensure effective termination of effector TH1 cells.
- Type
- article
- Published
- 2005-11-13
- Cited by
- 2,040
- References
- 32
- OpenAlex
- https://openalex.org/W2070631889
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24886582
Keywords
Effector, Cell biology, Galectin, Peripheral tolerance, Autoimmunity
References
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- Human Galectin-2: Novel Inducer of T Cell Apoptosis with Distinct Profile of Caspase Activation1
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- Functional diversity of T lymphocytes due to secretion of different cytokine patterns
- Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).
- Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells.
- Human Ecalectin, a Variant of Human Galectin-9, Is a Novel Eosinophil Chemoattractant Produced by T Lymphocytes*
- Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
- Requirement of Divalent Galactoside-binding Activity of Ecalectin/Galectin-9 for Eosinophil Chemoattraction*
- The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.
- Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
- Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
- Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.
- Lymphocyte responses and cytokines.
- Functional diversity of helper T lymphocytes
- Ah, sweet mystery of death! Galectins and control of cell fate.
- Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?
- Recombinant Galectin-1 and Its Genetic Delivery Suppress Collagen-Induced Arthritis via T Cell Apoptosis
- Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.
- Identification and Characterization of Galectin-9, a Novel β-Galactoside-binding Mammalian Lectin*
Cited by
- Galectins and neuroinflammation.
- The role of TIM-1 in enveloped virus entry
- Galectins in apoptosis.
- Integrating structure and function of 'tandem-repeat' galectins.
- Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection
- Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection
- Human Cytomegalovirus Upregulates Expression of the Lectin Galectin 9 via Induction of Beta Interferon
- Evolving Mechanistic Insights into Galectin Functions
- Immune-mediated antitumor effect by type 2 diabetes drug, metformin
- TIM-3 Genetic Variations Affect Susceptibility to Osteoarthritis by Interfering with Interferon Gamma in CD4+ T Cells
- Impact of Exogenous Galectin-9 on Human T Cells
- The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+ T cell responses
- Present and future perspectives on immunotherapy for advanced renal cell carcinoma: Going to the core or beating around the bush?
- Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis
- Immunomodulatory Monoclonal Antibodies in Combined Immunotherapy Trials for Cutaneous Melanoma
- Adaptive NKG2C+CD57+ Natural Killer Cell and Tim-3 Expression During Viral Infections
- Targeting the Immune Microenvironment in Acute Myeloid Leukemia: A Focus on T Cell Immunity
- Galectin-9 induces atypical ubiquitination leading to cell death in PC-3 prostate cancer cells
- Immunity and Immunopathology in acute viral infections
- The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
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