The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.
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Summary
The results strongly suggest that -574T>G and 4259G>T polymorphism of the Tim-3 might be associated with susceptibility to RA.
- Type
- article
- Published
- 2004-08-15
- Cited by
- 81
- References
- 28
- OpenAlex
- https://openalex.org/W1988567102
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33354754
Keywords
Single-nucleotide polymorphism, Genotype, Rheumatoid arthritis, Allele, Immunology
References
- Transcription: tantalizing times for T cells.
- Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
- Genetics of rheumatoid arthritis: confronting complexity
- Nebulized but not parenteral IFN-gamma decreases IgE production and normalizes airways function in a murine model of allergen sensitization.
- The TIM gene family: emerging roles in immunity and disease
- Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
- An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis.
- Asthma: an epidemic of dysregulated immunity
- A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases.
- Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2
- Molecular variations in Th1-specific cell surface gene Tim-3
- Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
- Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
- Functional diversity of helper T lymphocytes
- Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families.
- Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma.
- Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom.
- The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population.
- The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population.
- Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
Cited by
- Genetic variation and significant association of polymorphism rs7700944 G>A of TIM‐4 gene with rheumatoid arthritis susceptibility in Chinese Han and Hui populations
- Mechanisms of Tim-3 Signal Transduction in the Modulation of Downstream TCR Signaling
- Molecular Characterization of the Porcine TIM‐3 Gene
- TIM-3 and its regulatory role in immune responses.
- High Expression of Tim‐3 mRNA in Urinary Cells from Kidney Transplant Recipients with Acute Rejection
- T cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and susceptibility to pancreatic cancer
- Imbalanced Expression of T-bet and T Cell Immunoglobulin Mucin-3 in Patients with Aplastic Anaemia
- The Tim-3 ligand galectin-9 negatively regulates CD8+ alloreactive T cell and prolongs survival of skin graft.
- Underexpression of TIM-3 and Blunted Galectin-9-Induced Apoptosis of CD4+ T Cells in Rheumatoid Arthritis
- Expression of TIM‐3 on CD4+ and CD8+ T cells in the peripheral blood and synovial fluid of rheumatoid arthritis
- T-cell immunoglobulin and mucin domain 3 genetic polymorphisms are associated with rheumatoid arthritis independent of a shared epitope status.
- The TIM gene family regulates autoimmune and allergic diseases.
- Dynamic urinary proteomic analysis reveals stable proteins to be potential biomarkers
- TIM-3 as a new therapeutic target in systemic lupus erythematosus
- TIM Polymorphisms – Genetics and Function
- TIM-3 polymorphisms in type 1 diabetes families
- Fine mapping of T-cell immunoglobulin mucin domain gene 1 failed to detect a significant association with multiple sclerosis.
- Decreased Tim-3 and its correlation with Th1 cells in patients with immune thrombocytopenia.
- Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity.
- Expression of human TIM-3 and its correlation with disease activity in rheumatoid arthritis
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