The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+ T cell responses
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Summary
Recent studies characterizing the role of co-inhibitory receptor TIGIT in antitumor and other chronic CD8+ T cell responses are summarized.
- Type
- dissertation
- Published
- 2015-05-27
- Cited by
- 46
- References
- 10
- OpenAlex
- https://openalex.org/W26405604
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3029318
Keywords
Computer science, Humanities, Philosophy
References
- The TIGIT/CD226 axis regulates human T cell function
- Vstm3 is a Member of the CD28 Family and an Important Modulator of T Cell Function
- Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses
- The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.
- The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
- The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
- T-cell Immunoglobulin and ITIM Domain (TIGIT) Receptor/Poliovirus Receptor (PVR) Ligand Engagement Suppresses Interferon-γ Production of Natural Killer Cells via β-Arrestin 2-mediated Negative Signaling*
- The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
- Restoring function in exhausted CD8 T cells during chronic viral infection
- Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell–cell adhesion and signaling mechanism that requires cis-trans receptor clustering
Cited by
- TIGIT-CD155 Interactions in Melanoma: A Novel Co-Inhibitory Pathway with Potential for Clinical Intervention.
- TIGIT and Helios are highly expressed on CD4+ T cells in Sezary syndrome patients
- Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity
- The paired receptors TIGIT and DNAM-1 as targets for therapeutic antibodies
- Identification and characterization of HPV-independent cervical cancers
- TIGIT signalling pathway negatively regulates CD4+ T‐cell responses in systemic lupus erythematosus
- Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions
- mRNA Expression levels of genes involved in antitumor immunity: Identification of a 3-gene signature associated with prognosis of muscle-invasive bladder cancer
- Comprehensive investigating of cytokine and receptor related genes variants in patients with chronic hepatitis B virus infection
- Next generation of immune checkpoint therapy in cancer: new developments and challenges
- Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype
- PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function
- Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus
- Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma
- Expression of lymphocyte-activating gene 3 and T-cell immunoreceptor with immunoglobulin and ITIM domains in cutaneous melanoma and their correlation with programmed cell death 1 expression in tumor-infiltrating lymphocytes.
- Treatment of Murine Lupus with TIGIT-Ig
- CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function
- 新型免疫肿瘤治疗临床研究现状及应用前景
- TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells
- Novel Targets for the Treatment of Melanoma
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