IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing γδ T cells.
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Summary
Results suggest that LCs are required for the development of psoriasis-like lesions induced by IMQ in mice, and reduce levels of Th17-related cytokines in IMQ-treated skin lesions.
- Type
- article
- Published
- 2014-07-01
- Cited by
- 173
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2070176689
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205176202
Keywords
Psoriasis, Imiquimod, Langerin, Immunology, Interleukin 17
References
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- IL-23–Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization
- Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis1
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- Langerinneg conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice
- Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways
- Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin
- Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells.
- Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
- Aldara activates TLR7-independent immune defence
- Superantigenic staphylococcal exotoxins induce T-cell proliferation in the presence of Langerhans cells or class II-bearing keratinocytes and stimulate keratinocytes to produce T-cell-activating cytokines.
- Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity.
- Skin as a peripheral lymphoid organ: revisiting the concept of skin-associated lymphoid tissues.
- Epidermal turnover time.
- Imiquimod, a topical immune response modifier, induces migration of Langerhans cells.
- A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis.
- Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.
- Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
- Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
Cited by
- Vγ4 T Cells Inhibit the Pro-healing Functions of Dendritic Epidermal T Cells to Delay Skin Wound Closure Through IL-17A
- Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.
- Mechanisms of Psoriatic Plaque Formation in Mice
- Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice
- Wnt/β-Catenin and Wnt5a/Ca2+ Pathways Regulate Proliferation and Apoptosis of Keratinocytes in Psoriasis Lesions
- Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity
- Understanding inflammatory mechanisms in rheumatic diseases
- Cutting Edge: PD-1 Regulates Imiquimod-Induced Psoriasiform Dermatitis through Inhibition of IL-17A Expression by Innate γδ-Low T Cells
- Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis
- Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice
- The panoply of αβT cells in the skin.
- Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells
- Dermal γδ T Cells – What Have We Learned?
- Dermal Vγ4(+) γδ T cells possess a migratory potency to the draining lymph nodes and modulate CD8(+) T-cell activity through TNF-α production.
- Reactive Oxygen Species in Psoriasis and Psoriasis Arthritis: Relevance to Human Disease
- Is Wnt5a overexpression sufficient for generating a psoriasis‐like phenotype in transgenic mice?
- TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
- Human ß-Defensin 3 and Its Mouse Ortholog Murine ß-Defensin 14 Activate Langerhans Cells and Exacerbate Psoriasis-Like Skin Inflammation in Mice.
- Novel insights into the role of immune cells in skin and inducible skin-associated lymphoid tissue (iSALT)
- IL-6 Signaling in Myelomonocytic Cells Is Not Crucial for the Development of IMQ-Induced Psoriasis
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