Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis1
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Summary
The sole application of the innate TLR7/8 ligand IMQ rapidly induces a dermatitis closely resembling human psoriasis, critically dependent on the IL-23/IL-17 axis.
- Type
- article
- Published
- 2009-05-01
- Cited by
- 2,058
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W1939997832
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16962957
Keywords
Psoriasis, TLR7, Imiquimod, CD11c, Inflammation
References
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- Animal models of psoriasis and pustular psoriasis
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- Imiquimod: mode of action
- In Vitro and In Situ Expression of IL-23 by Keratinocytes in Healthy Skin and Psoriasis Lesions: Enhanced Expression in Psoriatic Skin
- Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice1
- Mouse Strain Differences in Plasmacytoid Dendritic Cell Frequency and Function Revealed by a Novel Monoclonal Antibody
- DC ablation in mice: promises, pitfalls, and challenges.
- In psoriasis lesional skin the type I interferon signaling pathway is activated, whereas interferon-alpha sensitivity is unaltered.
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- Animal models of psoriasis: a brief update
- Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells.
- Mouse models of psoriasis.
- Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: a double-blind, randomized, vehicle-controlled study.
- Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
- Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod.
Cited by
- Advances in understanding the pathogenesis of autoimmune disorders: focus on chemokines and lymphocyte trafficking
- Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease
- High‐risk melanoma patients: can unnecessary naevi biopsies be avoided?
- Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?
- Contribution of the IL-17 Pathway to Psoriasis and Psoriatic Arthritis
- IκBζ is a key driver in the development of psoriasis
- Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies
- Multi-glycoside of Tripterygium wilfordii Hook. f. ameliorates imiquimod-induced skin lesions through a STAT3-dependent mechanism involving the inhibition of Th17-mediated inflammatory responses
- Involvement of high mobility group box‐1 in imiquimod‐induced psoriasis‐like mice model
- Xenotransplantation Model of Psoriasis.
- Quercetin ameliorates imiquimod‐induced psoriasis‐like skin inflammation in mice via the NF‐&kgr;B pathway
- Skin-penetrating polymeric nanoparticles incorporated in silk fibroin hydrogel for topical delivery of curcumin to improve its therapeutic effect on psoriasis mouse model.
- Vγ4 T Cells Inhibit the Pro-healing Functions of Dendritic Epidermal T Cells to Delay Skin Wound Closure Through IL-17A
- Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review
- Development of psoriasis by continuous neutrophil infiltration into the epidermis
- Risankizumab for the treatment of moderate to severe psoriasis
- IL-17 May Be a Key Cytokine Linking Psoriasis and Hyperglycemia.
- Aldara-induced psoriasis-like skin inflammation: isolation and characterization of cutaneous dendritic cells and innate lymphocytes.
- Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants
- The tumor promoting roles of lymphocytes during RAS initiated inflammation and skin carcinogenesis
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