Topological Domains in Mammalian Genomes Identified by Analysis of Chromatin Interactions
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Summary
It is found that the boundaries of topological domains are enriched for the insulator binding protein CTCF, housekeeping genes, transfer RNAs and short interspersed element (SINE) retrotransposons, indicating that these factors may have a role in establishing the topological domain structure of the genome.
- Type
- article
- Published
- 2012-04-11
- Cited by
- 6,497
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W2070021921
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4301920
Keywords
CTCF, Genome, Chromatin, Biology, Chromosome conformation capture
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- Chromatin Insulators: Master Regulators of the Eukaryotic Genome
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- Doxorubicin, DNA torsion, and chromatin dynamics
- fourSig: a method for determining chromosomal interactions in 4C-Seq data
- The architecture of gene expression: integrating dispersed cis-regulatory modules into coherent regulatory domains.
- Two-dimensional segmentation for analyzing Hi-C data
- A CRISPR Connection between Chromatin Topology and Genetic Disorders
- CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription
- Spatially coordinated replication and minimization of expression noise constrain three-dimensional organization of yeast genome
- An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1
- 3D-GNOME: an integrated web service for structural modeling of the 3D genome
- Soft x-ray tomography reveals gradual chromatin compaction and reorganization during neurogenesis in vivo
- Disruption of the 3D cancer genome blueprint.
- Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data
- The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes
- Higher order assembly: folding the chromosome.
- Physical Forces May Cause the HoxD Gene Cluster Elongation
- At the base of colinear Hox gene expression: cis-features and trans-factors orchestrating the initial phase of Hox cluster activation.
- DNA replication through a chromatin environment
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