Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults.
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Summary
Experimental human carriage resulted in mucosal and systemic immunological responses that conferred protection against recolonization and invasive pneumococcal disease, suggesting that mucosal pneumococCal vaccination strategies may be important for vulnerable patient groups, particularly the elderly, who do not sustain carriage.
- Type
- article
- Published
- 2013-04-15
- Cited by
- 182
- References
- 39
- OpenAlex
- https://openalex.org/W2069890132
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46488193
Keywords
Medicine, Carriage, Streptococcus pneumoniae, Microbiology, Immunology
References
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- Th17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age.
- Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans.
- Potential role for mucosally active vaccines against pneumococcal pneumonia
- Characterisation of Regulatory T Cells in Nasal Associated Lymphoid Tissue in Children: Relationships with Pneumococcal Colonization
- Comparison of a New Multiplex Binding Assay versus the Enzyme-Linked Immunosorbent Assay for Measurement of Serotype-Specific Pneumococcal Capsular Polysaccharide IgG
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- The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.
- Vaccine-induced human antibodies to PspA augment complement C3 deposition on Streptococcus pneumoniae.
- Experimental Human Pneumococcal Carriage
- Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice.
- Recognition of pneumococcal isolates by antisera raised against PspA fragments from different clades.
- Effects of Ageing and Gender on Naturally Acquired Antibodies to Pneumococcal Capsular Polysaccharides and Virulence-Associated Proteins
- The pneumococcus: why a commensal misbehaves
- Epidemiological differences among pneumococcal serotypes.
Cited by
- Low Prevalence of Pneumococcal Carriage and High Serotype and Genotype Diversity among Adults over 60 Years of Age Living in Portugal
- Review: current and new generation pneumococcal vaccines.
- Relationship between nasopharyngeal carriage and acute otitis media due to Streptococcus pneumoniae among Finnish children aged less than two years
- Genetic stability of pneumococcal isolates during 35 days of human experimental carriage
- Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus
- Clinical and Microbiological Factors Associated with High Nasopharyngeal Pneumococcal Density in Patients with Pneumococcal Pneumonia
- Unveiling Time in Dose-Response Models to Infer Host Susceptibility to Pathogens
- Expression of Streptococcus pneumoniae Virulence-Related Genes in the Nasopharynx of Healthy Children
- Significance of immunity against lung pathogens in untreated Parkinson's disease.
- Promises and pitfalls of live attenuated pneumococcal vaccines
- Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage
- Serological response to 13-valent pneumococcal conjugate vaccine in children and adolescents with perinatally acquired HIV infection
- Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonisation requires both humoral and cellular immune responses
- Delayed reconstitution of B cell immunity to pneumococcus in HIV-infected Malawian children on antiretroviral therapy
- Association of Pneumococcal Carriage and Expression of Foxp3+ Regulatory T Cells and Th17 Cells in the Adenoids of Children
- Increased IgG but normal IgA anti-pneumococcal protein antibodies in lung of HIV-infected adults
- The potential of human nasal colonization with Streptococcus pneumoniae as a universal pneumococcal vaccine.
- Dynamics of pneumococcal carriage among day-care center attendees during the transition from the 7-valent to the higher-valent pneumococcal conjugate vaccines in Greece.
- Impact of Experimental Human Pneumococcal Carriage on Nasopharyngeal Bacterial Densities in Healthy Adults
- Age-related immune response to pneumococcal polysaccharide vaccination: lessons for the clinic
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