Regression of Dalton’s lymphoma in vivo via decline in lactate dehydrogenase and induction of apoptosis by a ruthenium(II)-complex containing 4-carboxy N-ethylbenzamide as ligand
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Summary
Modulation of M4-LDH by this compound in a T-cell lymphoma (Dalton’s Lymphoma: DL) vis a vis regression of the tumor in vivo is described to suggest that Ru(II)-CNEB is able to regress Dalton’'s lymphoma in vivo via declining M4 -LDH and inducing mitochondrial dysfunction–apoptosis pathway without producing any toxicity to the normal tissues.
- Type
- article
- Published
- 2009-12-01
- Cited by
- 38
- References
- 52
- OpenAlex
- https://openalex.org/W2085238957
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32046874
Keywords
Lactate dehydrogenase, In vivo, Apoptosis, Cytotoxicity, DNA fragmentation
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Cited by
- Antitumor effect of blister beetles: an ethno-medicinal practice in Karbi community and its experimental evaluation against a murine malignant tumor model.
- Effect of certain entomopathogenic fungi on oxidative stress and mortality of Periplaneta americana.
- Apoptosis of Dalton’s lymphoma due to in vivo treatment with emodin is associated with modulations of hydrogen peroxide metabolizing antioxidant enzymes
- Activation of Neuronal Nitric Oxide Synthase in Cerebellum of Chronic Hepatic Encephalopathy Rats is Associated with Up-regulation of NADPH-Producing Pathway
- Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines.
- 1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells
- One pot synthesis of Cu(II) 2,2'-bipyridyl complexes of 5-hydroxy-hydurilic acid and alloxanic acid: synthesis, crystal structure, chemical nuclease activity and cytotoxicity.
- Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation.
- Activation of p53 mediated glycolytic inhibition-oxidative stress-apoptosis pathway in Dalton's lymphoma by a ruthenium (II)-complex containing 4-carboxy N-ethylbenzamide.
- Targetting cancer with Ru(III/II)-phosphodiesterase inhibitor adducts: a novel approach in the treatment of cancer.
- Moderate grade hyperammonemia activates lactate dehydrogenase-4 and 6-phosphofructo-2-kinase to support increased lactate turnover in the brain slices
- Dimethyl sulfoxide activates tumor necrosis factorα-p53 mediated apoptosis and down regulates D-fructose-6-phosphate-2-kinase and lactate dehydrogenase-5 in Dalton's lymphoma in vivo.
- Acute Liver Failure in Rats Activates Glutamine-Glutamate Cycle but Declines Antioxidant Enzymes to Induce Oxidative Stress in Cerebral Cortex and Cerebellum
- Moderate Grade Hyperammonemia Induced Concordant Activation of Antioxidant Enzymes is Associated with Prevention of Oxidative Stress in the Brain Slices
- Structural characterization and cytotoxicity studies of ruthenium(II)–dmso–chloro complexes of chalcone and flavone derivatives
- Cytotoxic activity, cell imaging and photocleavage of DNA induced by a Pt(II) cyclophane bearing 1,2 diamino ethane as a terminal ligand
- New method for the speciation of ruthenium-based chemotherapeutics in human serum by conjoint liquid chromatography on affinity and anion-exchange monolithic disks.
- Cationic Ru(II), Rh(III) and Ir(III) complexes containing cyclic π-perimeter and 2-aminophenyl benzimidazole ligands: Synthesis, molecular structure, DNA and protein binding, cytotoxicity and anticancer activity
- Anticancer Activity of Garcinia morella on T-Cell Murine Lymphoma Via Apoptotic Induction
- In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines
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