Na(+)-Ca(2+) exchange in failing myocardium: friend or foe?
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Summary
The Na+-Ca2+ exchanger (NCX) is a cation transporting protein present in the plasma membrane of animal cells that contributes to relaxation in parallel with Ca2+ uptake by the sarcoplasmic reticulum (SR) Ca2-ATPase.
- Type
- letter
- Published
- 2000-09-29
- Cited by
- 30
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W2101812698
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23422134
Keywords
Chemistry
References
- Sodium-calcium exchange-mediated contractions in feline ventricular myocytes.
- Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium.
- Release of calcium from guinea pig cardiac sarcoplasmic reticulum induced by sodium-calcium exchange.
- Competition and redistribution among calcium transport systems in rabbit cardiac myocytes.
- Contribution of reverse-mode sodium-calcium exchange to contractions in failing human left ventricular myocytes.
- Role of Na+/Ca2+ exchange in endothelin‐1‐induced increases in Ca2+ transient and contractility in rabbit ventricular myocytes: pharmacological analysis with KB‐R7943
- Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes.
- Sodium Pump Inhibition, Enhanced Calcium Influx via Sodium‐Calcium Exchange, and Positive Inotropic Response in Cultured Heart Cells
- Mechanisms contributing to the cardiac inotropic effect of Na pump inhibition and reduction of extracellular Na
- The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes.
- Quantitation of Na/Ca exchanger function in single ventricular myocytes.
- Frequency dependence of Ca2+ release from the sarcoplasmic reticulum in human ventricular myocytes from end-stage heart failure.
- Alterations of calcium-regulatory proteins in heart failure.
- Sodium current‐induced calcium signals in isolated guinea‐pig ventricular myocytes.
- Intracellular Calcium Homeostasis in Cardiac Myocytes
- Influence of SR Ca2+-ATPase and Na+-Ca2+-exchanger on the force frequency relation
- Local regulation of the threshold for calcium sparks in rat ventricular myocytes: role of sodium‐calcium exchange
- Relaxation in rabbit and rat cardiac cells: species‐dependent differences in cellular mechanisms.
- Calcium content of the sarcoplasmic reticulum in isolated ventricular myocytes from patients with terminal heart failure.
- Contribution of the Sodium-Calcium Exchanger to Contractions in Immature Rabbit Ventricular Myocytes
Cited by
- The sodium/calcium exchanger family—SLC8
- Cardiac calcium handling in the mouse model of Duchenne Muscular Dystrophy
- Short term control of the cardiovascular system: Assessment with the isometric handgrip exercise
- EC-coupling in normal and failing hearts
- How do beta-blockers improve ventricular function in patients with congestive heart failure?
- Cardiac Na(+)-Ca(2+) exchange: molecular and pharmacological aspects.
- DEFECTIVE INTRACELLULAR Ca2+ HOMEOSTASIS CONTRIBUTES TO MYOCYTE DYSFUNCTION DURING VENTRICULAR REMODELLING INDUCED BY CHRONIC VOLUME OVERLOAD IN RATS
- Pharmacology of KB-R7943: a Na+-Ca2+ exchange inhibitor.
- Na+-Ca2+ Exchanger Remodeling in Pressure Overload Cardiac Hypertrophy*
- Targeted inactivation of the sodium‐calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization
- Reperfusion-induced Ins(1,4,5)P(3) generation and arrhythmogenesis require activation of the Na(+)/Ca(2+) exchanger.
- Heart failure – a challenge to our current concepts of excitation–contraction coupling
- [Na+]i handling in the failing human heart.
- Na+/Ca2+ exchanger plays a key role in inducing apoptosis after hypoxia in cultured guinea pig ventricular myocytes.
- Enhanced Sodium‐Calcium Exchange in the Infarcted Heart
- Molecular and Pharmacological Aspects
- Rate Dependence of [Na+]i and Contractility in Nonfailing and Failing Human Myocardium
- T‐Tubule Function in Mammalian Cardiac Myocytes
- The A BC o f S olute C arriers
- Na(+)-Ca(2+) exchange: three new tools.
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