Role of YKL-40 in the Angiogenesis, Radioresistance, and Progression of Glioblastoma*
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Summary
Light is shed on the mechanisms by which YKL-40 promotes tumor angiogenesis and malignancy, and thus provide a therapeutic target for tumor treatment.
- Type
- article
- Published
- 2011-03-08
- Cited by
- 247
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2052883386
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205308332
Keywords
Angiogenesis, Radioresistance, Cancer research, Metastasis, Tumor progression
References
- Experimental anti‐angiogenesis causes upregulation of genes associated with poor survival in glioblastoma
- Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains
- YKL-40 Is Elevated in Patients with Chronic Obstructive Pulmonary Disease and Activates Alveolar Macrophages1
- Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.
- Vascular-specific growth factors and blood vessel formation
- High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer.
- YKL-40 (cartilage gp-39) induces proliferative events in cultured chondrocytes and synoviocytes and increases glycosaminoglycan synthesis in chondrocytes.
- Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
- Synthetic Activation of Endogenous PI3K and Rac Identifies an AND-Gate Switch for Cell Polarization and Migration
- Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors.
- Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells*
- Transduction of a Mesenchyme-specific Gene Periostin into 293T Cells Induces Cell Invasive Activity through Epithelial-Mesenchymal Transformation*
- YKL-40, a secreted glycoprotein, promotes tumor angiogenesis
- Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen‐activated protein kinase
- Malignant gliomas in adults.
- Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells.
- Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages.
- Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages.
- Expression of vascular endothelial growth factor‐A and mRNA stability factor HuR in human astrocytic tumors
- Identification of proteins secreted by human osteoblastic cells in culture
Cited by
- Tumor-derived mural-like cells coordinate with endothelial cells: role of YKL-40 in mural cell-mediated angiogenesis
- Plasma YKL-40 in Inuit and Danes.
- Prognostic Gene Discovery in Glioblastoma Patients using Deep Learning
- Protein and mRNA levels of YKL-40 in high-grade glioma.
- Estimation of a common covariance matrix for multiple classes with applications in meta- and discriminant analysis
- Analysis of the Mechanism by which YKL-40 Promotes Glioma Cell Migration
- REGULATION OF YKL-40 IN STERILE INFLAMMATION AND ITS ROLE IN GLIOBLASTOMA IN VIVO
- Overexpression of chitinase like protein YKL-40 in leukemia patients
- Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic Datasets
- Observational and genetic plasma YKL‐40 and cancer in 96,099 individuals from the general population
- Définition d’une glyco-signature spécifique des cellules souches tumorales de glioblastome et développement d’outils pour la caractérisation cellulaire
- Elevated plasma YKL‐40 as a prognostic indicator in patients with idiopathic pulmonary arterial hypertension
- ‘From the core to beyond the margin’: a genomic picture of glioblastoma intratumor heterogeneity
- The role of YKL-40 in the progression of glioblastoma
- YKL-40 and genetic status of CHI3L1 in a large group of asthmatics
- Brain tumor microarray data analyzed using clustering and novel consensus clustering techniques
- YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer
- RelB/p50 complexes regulate cytokine-induced YKL-40 expression
- DEPENDENCE OF YKL-40 mRNA TISSUE LEVELS ON KRAS MUTATION STATUS IN COLORECTAL CANCER - PRELIMINARY RESULTS
- YKL-40: may be use as a new inflammatory biomarker in obstructive sleep apnea syndrome?
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