Plasma leptin concentrations during extended fasting and graded glucose infusions: relationships with changes in glucose, insulin, and FFA.
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Summary
The data indicate that in lean healthy subjects, physiological changes in glycemia and insulinemia significantly alter plasma FFA and leptin concentrations, and the increases in leptin concentrations demonstrate dose-dependent relationships that appear to relate to changes in FFA levels as well as toChanges in glyCEmia/insulinemi.
- Type
- article
- Published
- 2001-10-01
- Cited by
- 48
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2049613309
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24736811
Keywords
Internal medicine, Endocrinology, Leptin, Insulin, Liter
References
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- Statistical Principles in Experimental Design
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- Rat adipose ob mRNA levels in states of altered circulating glucose and insulin.
- The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity, and age in women.
- Entrainment of the diurnal rhythm of plasma leptin to meal timing.
- Insulin increases leptin mRNA expression in abdominal subcutaneous adipose tissue in humans.
- Physiological insulinemia acutely modulates plasma leptin.
- Effects of nutritional status and aging on leptin gene expression in mice: importance of glucose.
- Effects of acute hyperinsulinemia on plasma leptin concentrations in insulin-sensitive and insulin-resistant Pima Indians.
- Acute changes in free-fatty acids (FFA) do not alter serum leptin levels
- Regulation of ob gene mRNA levels in cultured adipocytes
- Transcriptional regulation of leptin gene promoter in rat
- High-fat meals reduce 24-h circulating leptin concentrations in women.
- Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves
Cited by
- Protein metabolism and nutritional requirements in critically ill children = Eiwitmetabolisme en voedingsbehoefte van ernstig zieke kinderen
- Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease
- Alcohol intake modulates hormonal activity of adipose tissue.
- The nutritional regulation of oocyte quality and early embryo development in cattle
- Reproduction and plasma concentrations of leptin, insulin and insulin-like growth factor 1 in growth-hormone-transgenic female sheep before and after artificial insemination.
- Oral and intravenous carbohydrate challenges decrease active ghrelin concentrations and alter hormones related to control of energy metabolism in horses.
- Rethinking leptin and insulin action: therapeutic opportunities for diabetes.
- Insulin determines leptin responses during a glucose challenge in fed and fasted rats
- Amylin and selective glucoregulatory peptide alterations during prolonged exercise.
- The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women.
- 短期絶食後に再給餌されたヒツジにおける血中レプチン濃度の変化とグルコース・インシュリン・IGF-1の血中濃度変化との関係
- Hyperleptinemia is associated with hypertension, systemic inflammation and insulin resistance in overweight but not in normal weight men.
- Relationships between plasma concentrations of leptin and other metabolic hormones in GH-transgenic sheep infused with glucose.
- The role of leptin in idiopathic chronic pancreatitis?
- Lack of direct effect of moderate hyperleptinemia to improve endothelial function in lean rat aorta: role of calorie restriction.
- Early morning rise in hypothalamic-pituitary-adrenal activity: a role for maintaining the brain's energy balance.
- Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans
- Regulation of peripheral metabolism by substrate partitioning in the brain
- Hyperglycemia in children with meningococcal sepsis and septic shock: the relation between plasma levels of insulin and inflammatory mediators.
- Prognostic effect of circulating adiponectin in a randomized 2 x 2 trial of low-dose tamoxifen and fenretinide in premenopausal women at risk for breast cancer.
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