Transcriptional regulation of leptin gene promoter in rat
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Summary
It is postulated that the region from −101 to −83 of the leptin gene is responsible for glucose/insulin stimulation of transcription, and that Sp1 is somehow involved in this regulation.
- Type
- article
- Published
- 1999-07-16
- Cited by
- 57
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2063445735
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41977316
Keywords
Leptin, Molecular biology, Biology, Transfection, Gene
References
- Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P‐4501A1 gene.
- The ob Gene and Insulin: A Relationship Leading to Clues to the Understanding of Obesity
- Sp1‐mediated transcriptional activation is repressed by Sp3.
- Identification and characterization of hepatocyte-specific regulatory regions of the rat pyruvate kinase L gene. The synergistic effect of multiple elements.
- Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats.
- Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.
- Tissue-specific in vitro transcription from the mouse albumin promoter.
- Transcriptional regulatory regions for expression of the rat pyruvate kinase M gene.
- Sp1 Mediates Glucose Activation of the Acetyl-CoA Carboxylase Promoter (*)
- Transcriptional regulatory region for expression of the rat ATP citrate-lyase gene.
- A GC-rich Region Containing Sp1 and Sp1-like Binding Sites Is a Crucial Regulatory Motif for Fatty Acid Synthase Gene Promoter Activity in Adipocytes
- Positional cloning of the mouse obese gene and its human homologue
- Obese Gene Expression Alters the Ability of 30A5 Preadipocytes to Respond to Lipogenic Hormones*
- Transient increase in obese gene expression after food intake or insulin administration
- Advantages of firefly luciferase as a reporter gene: application to the interleukin-2 gene promoter.
- Insulin‐ and polyunsaturated fatty acid‐responsive region(s) of rat ATP citrate‐lyase gene promoter
- Modulation of Insulin Activities by Leptin
- Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.
- Cloning of the Promoter-Regulatory Region of the Murine Growth Hormone Receptor Gene
- A method for increasing the sensitivity of chloramphenicol acetyltransferase assays in extracts of transfected cultured cells.
Cited by
- Nutritional and insulin regulation of leptin gene expression.
- The Coordinate Regulation of Insulin, Insulin Receptors and Lipogenic Enzymes by Insulin and Dietary Fat
- Effects of Trecadrine®, a β3-adrenergic agonist, on leptin secretion, glucose and lipid metabolism in isolated rat adipocytes
- Transcriptional regulation by insulin: from the receptor to the gene.
- Leptin gene polymorphisms and their phenotypic associations.
- Effects of arachidonic acid on leptin secretion and expression in primary cultured rat adipocytes
- Emerging role of leptin in rheumatoid arthritis
- Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissue.
- Transcriptional regulation of insulin receptor gene promoter in rat hepatocytes.
- Activation of the nuclear transcription factor SP-1 by insulin rapidly increases the expression of protein kinase C delta in skeletal muscle.
- Leptin secretion is related to glucose-derived lipogenesis in isolated adipocytes
- Gene structure and expression of leptin in Chinese perch.
- Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet.
- Regulation and Function of Collagenous Repeat Containing Sequence of 26‐kDa Protein Gene Product “Cartonectin”
- Mutation in the Sp1 motif of the bovine leptin gene affects its expression
- Effects of vanadate on leptin production from isolated rat adipocytes
- Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways.
- Transcriptional regulation of the leptin gene promoter in rat GH3 pituitary and C6 glioma cells.
- Sp1 is required for glucose-induced transcriptional regulation of mouse vesicular glutamate transporter 2 gene.
- Plasma leptin concentrations during extended fasting and graded glucose infusions: relationships with changes in glucose, insulin, and FFA.
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