Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation.
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Summary
The data suggest that reverse glial glutamate uptake may trigger neuronal death through preferential activation of extrasynaptic NMDAR-related pathways.
- Type
- article
- Published
- 2009-04-01
- Cited by
- 78
- References
- 50
- OpenAlex
- https://openalex.org/W2049611687
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35733208
Keywords
Biology, NMDA receptor, Glutamate receptor, Neuroscience, Programmed cell death
References
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- Cloning and expression of a rat brain L-glutamate transporter
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- The role of receptor diffusion in the organization of the postsynaptic membrane
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- Localization of neuronal and glial glutamate transporters.
- NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
Cited by
- Phénomènes neuro-inflammatoires au cours de l'état de mal épileptique induit par le soman. Correction par des combinaisons atropine-kétamine.
- In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction
- The induction of traumatic brain injury by blood brain barrier disruption
- Inositol 1,4,5-tripshosphate receptor, calcium signaling and polyglutamine expansion disorders
- Excitotoxic ATP and Glutamate Signalling during Central Nervous System Ischaemia
- Modèle progressif de la maladie de parkinson après dysfonctionnement aigu des transporteurs du glutamate dans la substance noire chez le rat.
- Defining mechanisms of neurodegeneration associated with protein misfolding diseases
- Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS
- Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions
- Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
- Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice.
- Extrasynaptic NMDA receptor involvement in central nervous system disorders.
- Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease.
- Cyclin D1 Induction Preceding Neuronal Death via the Excitotoxic NMDA Pathway Involves Selective Stimulation of Extrasynaptic NMDA Receptors and JNK Pathway
- Revisiting the function of extrasynaptic NMDA receptor in excitotoxicity Running title: NMDA receptor and excitotoxicity
- Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice.
- NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors
- NMDA receptor activity determines neuronal fate: location or number?
- Role of Inositol 1,4,5-Trishosphate Receptors in Pathogenesis of Huntington's Disease and Spinocerebellar Ataxias
- Mitochondrial Dysfunction Induced by Nuclear Poly(ADP-Ribose) Polymerase-1: a Treatable Cause of Cell Death in Stroke
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