Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform
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Summary
Because glucocorticoid receptor β inhibits α-glucocortin-driven cutaneous cell–mediated transactivation of target genes, the increased expression of glucocortsolone receptor β in inflammatory cells might be a critical mechanism for conferring glucoc Corticoid resistance.
- Type
- article
- Published
- 2000-05-01
- Cited by
- 284
- References
- 19
- OpenAlex
- https://openalex.org/W2048445979
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28491373
Keywords
Glucocorticoid receptor, Glucocorticoid, Endocrinology, Internal medicine, Prednisolone
References
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- Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β
Cited by
- Clinical and molecular aspects of glucocorticoid resistant asthma
- P-Glycoprotein Transporter Expression on A549 Respiratory Epithelial Cells Is Positively Correlated With Intracellular Dexamethasone Levels
- Pharmacogenetics of asthma.
- Negative Affectivity and Inflammation: Moderation by the Glucocorticoid Receptor-9beta Polymorphism
- Application of systems biology to dissect glucocorticoid receptor function
- Receptor concentration affects glucocorticoid action
- Investigating the role of potential genetic markers that can predict risk for steroid refractory inflammatory bowel disease
- Reconfigurable hybrid interface for molecular marker diagnostics and in-situ reporting
- Systems Biology Based Approaches to Identify Biomarkers in Seasonal Allergic Rhinitis
- The Properties of Circulating Fibrocytes in Severe Asthma
- Efeito dos glicocorticóides na resposta inflamatória induzida por LPS em cultura de células primárias fronto-corticais de ratos neonatos.
- The allergic march from Staphylococcus aureus superantigens to immunoglobulin E.
- Neuroendocrine-Immune Interactions in Rheumatoid Arthritis: Mechanisms of Glucocorticoid Resistance
- Neural immune pathways and their connection to inflammatory diseases
- The glucocorticoid receptor beta-isoform: a perspective on its relevance in human health and disease.
- Naturally occurring C-terminal splice variants of nuclear receptors
- Glucocorticosteroids: current and future directions
- The Effects of Glucocorticoids on Trabecular Meshwork and its Role in Glaucoma
- Blockade of interleukin‐6 receptor enhances the anti‐arthritic effect of glucocorticoids without decreasing bone mineral density in mice with collagen‐induced arthritis
- Is there a role for glucocorticoid receptor beta in asthma?
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