In vitro and in vivo modulation of alpha- and beta-glucocorticoid-receptor mRNA in human bronchial epithelium.
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Summary
Normalization of the downregulation of GR mRNA expression in bronchial epithelial cells is explained by the pharmacokinetics of inhaled budesonide in the human lung.
- Type
- article
- Published
- 1997-03-01
- Cited by
- 41
- References
- 0
- OpenAlex
- https://openalex.org/W2012757036
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23290814
Keywords
Downregulation and upregulation, Glucocorticoid receptor, Budesonide, Glucocorticoid, Inhalation
References
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- Regulation of glucocorticoid receptor in nasal polyps by systemic and intranasal glucocorticoids
- Expression of human glucocorticoid receptor beta of peripheral blood mononuclear cells in patients with severe autoimmune hepatitis.
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- Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease.
- Glucocorticoid receptor expression in inflammatory bowel disease: evidence for a mucosal down‐regulation in steroid‐unresponsive ulcerative colitis
- Alpha and beta glucocorticoid receptors: Relevance in airway diseases
- Glucocorticoid and Estrogen Receptors Are Reduced in Mitochondria of Lung Epithelial Cells in Asthma
- Pharmacological characterization of glucocorticoid receptors in primary human bronchial epithelial cells.
- Glucocorticoid receptor mRNA levels in bronchial epithelial cells of patients with COPD: influence of glucocorticoids.
- Heterogeneity in mechanisms influencing glucocorticoid sensitivity: the need for a systems biology approach to treatment of glucocorticoid-resistant inflammation.
- Glucocorticoid receptor beta in acute and chronic inflammatory conditions: clinical implications.
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