Spared nerve injury: an animal model of persistent peripheral neuropathic pain
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Summary
The spared nerve injury model differs from the Chung spinal segmental nerve, the Bennett chronic constriction injury and the Seltzer partial sciatic nerve injury models in that the co‐mingling of distal intact axons with degenerating axons is restricted, and it permits behavioral testing of the non‐injured skin territories adjacent to the denervated areas.
- Type
- article
- Published
- 2000-08-01
- Cited by
- 2,236
- References
- 57
- OpenAlex
- https://openalex.org/W2047010161
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24918287
Keywords
Neuropathic pain, Peripheral nerve injury, Medicine, Denervation, Sciatic nerve
References
- Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons
- Na+ channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation
- Collateral Sprouting of Uninjured Primary Afferent A-Fibers into the Superficial Dorsal Horn of the Adult Rat Spinal Cord after Topical Capsaicin Treatment to the Sciatic Nerve
- An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
- Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain
- Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn‐induced secondary hyperalgesia in man: a double‐blind, cross‐over comparison with morphine and placebo
- Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine
- Treatment of a chronic allodynia‐like response in spinally injured rats: effects of systemically administered excitatory amino acid receptor antagonists
- The pathophysiology of chronic pain--increased sensitivity to low threshold A beta-fibre inputs.
- Peripheral nerve injury triggers central sprouting of myelinated afferents
- Deafferentation in animals as a model for the study of pain: an alternative hypothesis
- Painful neuropathy: altered central processing maintained dynamically by peripheral input
- The development of chronic mechanical hyperalgesia, autotomy and collateral sprouting following sciatic nerve section in rat
- NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride
- Myelinated afferents signal the hyperalgesia associated with nerve injury
- The production and prevention of experimental anesthesia dolorosa
- Does a neuroimmune interaction contribute to the genesis of painful peripheral neuropathies?
- The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury.
- A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
- Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand.
Cited by
- Attenuation of neuropathic pain by segmental and supraspinal activation of the dorsal column system in awake rats.
- Drug Addiction and Chronic Pain: A Review of Animal Models
- Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms.
- Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.
- Reversible attenuation of neuropathic-like manifestations in rats by lesions or local blocks of the intralaminar or the medial thalamic nuclei.
- TRP channels and pain.
- Attenuated cold sensitivity in TRPM8 null mice.
- The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain
- Evaluation Tools and Animal Models of Peripheral Neuropathies
- Constitutive Activity at the Cannabinoid CB1 Receptor and Behavioral Responses
- POST‐SURGICAL NEUROPATHIC PAIN
- Rapid Pain Modulation with Nuclear Receptor Ligands
- Modulation of neuropathic pain by a glial-derived factor.
- Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat.
- Tests and models of nociception and pain in rodents.
- L6 spinal nerve ligation produces prolonged development of mechanical allodynia and gradual increase of GFAP on ipsilateral dorsal horn
- ARA290 in a rat model of inflammatory pain.
- Descending Facilitation Maintains Long-term Spontaneous Neuropathic Pain
- Gosha-jinki-gan reduced oxaliplatin-induced hypersensitivity to cold sensation and its effect would be related to suppression of the expression of TRPM8 and TRPA1 in rats
- Menin regulates spinal glutamate-GABA balance through GAD65 contributing to neuropathic pain
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