The production and prevention of experimental anesthesia dolorosa
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Summary
It is suggested that the untreated animals have a type of anesthesia dolorosa caused by the generation of nerve impulses in the cut and sprouting peripheral nerve fibers, and the local release of norepinephrine by sympathetic fibers in the neuroma may be one of the factors producing sufficient peripheral afferent discharge to cause autotomy.
- Type
- article
- Published
- 1979-04-01
- Cited by
- 219
- References
- 13
- OpenAlex
- https://openalex.org/W2003581757
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29953231
Keywords
Autotomy, Medicine, Anesthesia, Sciatic nerve, Neuroma
References
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- Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons.
- Effects of central lesions on disorders produced by multiple dorsal rhizotomy in rats.
- Deafferentation hypersensitivity in the rat after dorsal rhizotomy: A possible animal model of chronic pain
- The Pharmacological Basis of Therapeutics
- The Pharmacological Basis of Therapeutics
Cited by
- Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury.
- Neonatal guanethidine sympathectomy suppresses autotomy and prevents changes in spinal and supraspinal monoamine levels induced by peripheral deafferentation in rats
- Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade.
- An in vivo study of tricalcium phosphate and glutaraldehyde crosslinking gelatin conduits in peripheral nerve repair.
- The suggested mechanisms of chronic pain and the rationale of neurosurgical treatment.
- The quality and extension of nerve fibre regeneration in the centrocentral anastomosis of the peripheral nerve.
- Effects of valproic Acid on axonal regeneration and recovery of motor function after peripheral nerve injury in the rat.
- Proceedings of the 8th European Congress of Neurosurgery, Barcelona, September 6–11, 1987
- The history of neuroscience in autobiography
- Protective immunity of rAd5/NR2B vaccine against concomitant aversiveness of spontaneous neuropathic pain following spinal nerve ligation injury.
- Self-mutilation in patients after nerve injury may not be due to deafferentation pain: a case report.
- Phenoxybenzamine in the treatment of causalgia. Report of 40 cases.
- Functional recovery guided by an electrospun silk fibroin conduit after sciatic nerve injury in rats
- Patellofemoral pain syndrome in young women
- Substance P in peripheral sensory processes.
- An experimental painful peripheral neuropathy due to nerve constriction. I. Axonal pathology in the sciatic nerve.
- Sympathetically Maintained Pain
- Quadriceps muscle performance in sitting and standing in young women with patellofemoral pain syndrome and young healthy women
- The effects of oral morphine and buprenorphine on autotomy following brachial nerve sections in rat
- Neuropathic pain behavior in rats depends on the afferent input from nerve-end neuroma including histamine-sensitive C-fibers.
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