Cell cycle, CDKs and cancer: a changing paradigm
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Summary
Genetic evidence suggests that tumour cells may also require specific interphase CDKs for proliferation, and selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.
- Type
- review
- Published
- 2009-03-01
- Cited by
- 3,840
- References
- 177
- OpenAlex
- https://openalex.org/W2046024621
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2613411
Keywords
Cyclin-dependent kinase, Cell cycle, Cell biology, Biology, Cyclin-dependent kinase 1
References
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- The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cells
- ATR: An Essential Regulator of Genome Integrity
- Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity
- The anaphase promoting complex/cyclosome: a machine designed to destroy
- Cyclin D-dependent kinases, INK4 inhibitors and cancer.
- Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C
- Kinase-independent function of cyclin E.
- Ubiquitin ligases: cell-cycle control and cancer
Cited by
- Development of an shRNA screen to identify mediators of cellular senescence in human breast epithelial cells
- Primers on Molecular Pathways – Cycling toward Pancreatic Cancer
- Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastoma multiforme.
- Targeting the cell cycle in esophageal adenocarcinoma: an adjunct to anticancer treatment.
- Proteomic analysis of the molecular response of Raji cells to maslinic acid treatment.
- Inhibitory effects of sepiapterin on vascular endothelial growth factor-a-induced proliferation and adhesion in human umbilical vein endothelial cells
- Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells
- Mitotic and mitogenic Wnt signalling
- Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.
- Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression
- Tumor-suppressive effects of CDK8 in endometrial cancer cells
- D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells
- The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles.
- Antagonistic Interplay between Necdin and Bmi1 Controls Proliferation of Neural Precursor Cells in the Embryonic Mouse Neocortex
- Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells.
- Cross-talk between the circadian clock and the cell cycle in cancer
- Induction of Cell Cycle Arrest and Apoptosis by Physcion, an Anthraquinone Isolated From Rhubarb (Rhizomes of Rheum tanguticum), in MDA-MB-231 Human Breast Cancer Cells
- Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer
- Thyrospheres From Normal or Malignant Thyroid Tissue Have Different Biological, Functional, and Genetic Features.
- NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation
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